Description

(2R, 4'S, 8'R)-α-Tocopherol is a specific, natural stereoisomer of vitamin E, distinguished by its precise (2R, 4'S, 8'R) configuration, which is critical for optimal biological activity. This high-purity compound is essential for applications requiring the most potent and bioavailable form of vitamin E. It is a vital ingredient for the pharmaceutical, nutraceutical, and premium cosmetic industries, where its powerful antioxidant properties and specific stereochemistry are paramount for product efficacy and regulatory compliance.

Application

• Pharmaceutical Formulations: Used as an active pharmaceutical ingredient (API) in prescription and over-the-counter medications for treating vitamin E deficiency and related conditions.
• Dietary Supplements & Nutraceuticals: A key component in high-end multivitamins, softgel capsules, and functional foods due to its superior bioavailability and antioxidant benefits for cellular health.
• Cosmetics & Personal Care: Incorporated into anti-aging serums, creams, and sunscreens to protect skin from oxidative stress and UV-induced damage, improving skin texture and stability.
• Animal Nutrition (Premix): Added to premium feed for livestock, poultry, and pets to enhance immune function, reproductive health, and meat quality.
• Food Fortification: Employed to fortify edible oils, dairy alternatives, and infant formula, preventing rancidity and increasing nutritional value.
• Biochemical Research: Serves as a critical standard and reagent in life science research for studying antioxidant mechanisms, lipid peroxidation, and cell signaling pathways.

Basic Information

Product Name	(2R, 4'S, 8'R)-α-Tocopherol
CAS No.	78656-13-0
Molecular Formula	C29H50O2
Molecular Weight	430.71 g/mol
Synonyms	d-α-Tocopherol; RRR-α-Tocopherol; Natural Vitamin E; (R,R,R)-α-Tocopherol; 2R,4'R,8'R-α-Tocopherol; 5,7,8-Trimethyltocol; Vitamin E (natural form); EINECS 278-769-9
EINECS	278-769-9

Quality Control

Our (2R, 4'S, 8'R)-α-Tocopherol is manufactured under strict quality systems to meet the highest standards for purity and stereochemical integrity. Each batch is rigorously tested against relevant pharmacopeial monographs (USP, Ph. Eur., JP) and in-house specifications. A comprehensive Certificate of Analysis (COA) detailing assay, stereoisomeric purity, and impurity profiles is provided to ensure full traceability and compliance for your regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen) at 2-8°C to minimize oxidation and ensure long-term stability. Keep the container in a cool, dry, and well-ventilated area away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	Clear, pale yellow to brownish viscous oil
Identification (IR)	Conforms to standard
Assay (HPLC)	≥ 96.0%
Stereoisomeric Purity (HPLC)	≥ 98.0% (2R,4'R,8'R)-α-Tocopherol
Specific Rotation [α]20/D	+0.20° to +0.30°
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.