Description

Insulin, Leu(B24)- is a synthetic analog of human insulin, specifically modified at the B24 position where the phenylalanine residue is replaced by leucine. This structural modification is of significant interest for advanced biochemical research into insulin's structure-activity relationships and receptor binding mechanisms. It serves as a critical reference standard and intermediate for pharmaceutical R&D, particularly in the development of novel insulin therapeutics and metabolic disorder studies. This high-purity compound is essential for academic institutions, contract research organizations (CROs), and biotechnology companies engaged in peptide hormone research.

Application

• Pharmaceutical Reference Standard: Used as a high-purity calibrant in analytical methods (HPLC, MS) for quality control of insulin-based drugs.
• Biochemical Research: Critical for studying the impact of specific amino acid substitutions on insulin's folding, stability, and biological activity.
• Drug Discovery & Development: Serves as a key intermediate or precursor in the research phase for designing new insulin analogs with modified pharmacokinetic profiles.
• Metabolic Studies: Employed in in vitro and ex vivo experiments to investigate insulin signaling pathways and receptor interactions.
• Peptide Chemistry Studies: Used as a model compound in methodological development for peptide synthesis, purification, and characterization.

Basic Information

Item	Detail
Product Name	Insulin, Leu(B24)-
CAS No.	78564-75-7
Molecular Formula	C257H383N65O77S6
Molecular Weight	5807.9 g/mol
Synonyms	Leu(B24)-Insulin; [LeuB24]-Insulin; Insulin B24-Leucine analog; Human Insulin [LeuB24]; Insulin (Leu(B24)); L-LeucineB24-Insulin; 24B-Leucine-Insulin; Des-PheB24,LeuB24-Insulin
EINECS	Contact for details

Quality Control

Our Insulin, Leu(B24)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided, documenting critical parameters such as assay purity, related substances, and residual solvents. We support compliance with relevant GMP guidelines for active pharmaceutical ingredients (APIs) and intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For extended storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 10.0%
Peptide Content	≥ 80.0%
Biological Activity	Assessed by in vitro assay (Available on request)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.