Description

Insulin, Leu(B25)- CAS NO 78564-74-6 is a specific, chemically modified analog of human insulin where the phenylalanine at position B25 is substituted with leucine. This modification is of significant interest in pharmaceutical research for studying insulin's structure-activity relationships, receptor binding kinetics, and metabolic stability. It serves as a critical intermediate or reference standard for researchers and developers in the biopharmaceutical sector focused on next-generation diabetes therapies and metabolic disorder research.

Application

• Pharmaceutical Research & Development: As a key reference standard for analytical method development and validation in insulin analog studies.
• Structure-Activity Relationship (SAR) Studies: To investigate the impact of specific amino acid substitutions on insulin's biological potency and duration of action.
• Metabolic Research: Used in preclinical studies to understand insulin signaling pathways and glucose metabolism modulation.
• Bioconjugation & Protein Engineering: Serves as a starting material or model peptide for developing novel insulin derivatives with tailored properties.
• Quality Control Laboratories: Employed as a high-purity comparator in the QC testing of insulin-based drug substances and products.
• Academic Research: For fundamental studies in endocrinology, peptide chemistry, and hormone-receptor interactions.

Basic Information

Product Name	Insulin, Leu(B25)- CAS NO 78564-74-6
CAS No.	78564-74-6
Molecular Formula	C257H383N65O77S6
Molecular Weight	~5807.9 g/mol
Synonyms	Leu(B25)-Insulin; [LeuB25]-Insulin; Insulin B25-Leucine analog; Human Insulin (B25-Leu); Insulin LeuB25; B25-Leucine Insulin; 78564-74-6; Insulin analog (Leu for Phe at B25)
EINECS	Contact for details

Quality Control

Our Insulin, Leu(B25)- is produced and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical parameters such as purity, peptide content, and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content (UV)	≥ 80.0%
Water Content (KF)	≤ 10.0%
Acetate Content (HPLC)	≤ 15.0%
Biological Activity	Assessed per customer requirement

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.