Description

1-Boc-3-Isobutylpiperazine (CAS NO 78551-93-6) is a high-purity, protected piperazine derivative that serves as a critical building block in advanced organic synthesis. Its primary value lies in providing a versatile nitrogen-containing scaffold with orthogonal protecting group chemistry, enabling precise molecular construction. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, particularly for the synthesis of complex active pharmaceutical ingredients (APIs) and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of drug candidates, especially those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Research: Used as a building block for developing novel pesticides and herbicides with specific biological activity.
• Peptidomimetics & Bioactive Molecule Synthesis: The Boc-protected amine and piperazine core are instrumental in creating peptide analogs and other bioactive compounds.
• Ligand & Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in asymmetric catalysis and metal complexes.
• Custom Chemical Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects requiring protected amine functionalities.
• Academic & Institutional Research: A valuable reagent for methodological studies in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	1-Boc-3-Isobutylpiperazine
CAS No.	78551-93-6
Molecular Formula	C13H26N2O2
Molecular Weight	242.36 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-3-isobutylpiperazine; tert-Butyl 3-isobutylpiperazine-1-carboxylate; 3-Isobutyl-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; 1-Boc-3-(2-methylpropyl)piperazine; N-Boc-3-isobutylpiperazine; Piperazine, 3-(2-methylpropyl)-, 1-(1,1-dimethylethyl) ester; Boc-3-isobutylpiperazine
EINECS	Contact for details

Quality Control

Our 1-Boc-3-Isobutylpiperazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and identity confirmation. We provide Certificates of Analysis (COA) with every shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.