Description

Proteinase, Aspartic CAS NO 78169-47-8 is a specialized proteolytic enzyme belonging to the aspartic endopeptidase family, recognized for its unique catalytic mechanism involving two aspartic acid residues. This enzyme is critical for the selective hydrolysis of peptide bonds, particularly in acidic environments, making it a valuable tool for targeted protein digestion and modification. It is essential for research and development in the life sciences, as well as for industrial processes in biotechnology and pharmaceutical manufacturing where precise protein manipulation is required.

Application

• Biopharmaceutical Research: Used for the controlled digestion of monoclonal antibodies and other therapeutic proteins for structural analysis, peptide mapping, and characterization.
• Proteomics & Mass Spectrometry: A key reagent for protein sample preparation, enabling efficient and specific cleavage for bottom-up proteomic analysis.
• Enzyme Structure-Function Studies: Employed as a model enzyme in biochemical research to study the mechanism and inhibition of aspartic proteases.
• Food Protein Hydrolysis: Applied in the modification of food proteins to improve functional properties like solubility or to generate bioactive peptides.
• Diagnostic Kit Manufacturing: Incorporated as a component in enzymatic assay kits and diagnostic reagents requiring specific proteolytic activity.

Basic Information

Product Name	Proteinase, Aspartic
CAS No.	78169-47-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Aspartic Protease; Aspartic Endopeptidase; Aspartic Proteinase; Acid Protease; Pepsin-like Enzyme; Cathepsin D (related family); HIV-1 Protease (related family); EC 3.4.23
EINECS	Contact for details

Quality Control

Our Proteinase, Aspartic is produced and tested under a rigorous quality management system. Each batch is characterized for key activity and purity parameters to ensure consistency and performance for critical research and industrial applications. A comprehensive Certificate of Analysis (COA) detailing assay, specific activity, and purity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Activity)	Conforms
Assay (Specific Activity)	≥ [Value] units/mg protein
Purity (SDS-PAGE)	≥ 90%
Protein Content (Biuret)	Reported on COA
pH (in solution)	Optimum range provided on COA
Loss on Drying	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.