Description

Aztreonam is a synthetic monobactam antibiotic belonging to the β-lactam class, specifically designed to be highly resistant to β-lactamases. This product is essential for research and development in the pharmaceutical sector, particularly in the study of novel antibacterial agents and resistance mechanisms. It is primarily utilized by pharmaceutical manufacturers, research institutions, and academic laboratories engaged in antimicrobial development and microbiological studies.

Application

• As a key reference standard and active pharmaceutical ingredient (API) in the development and quality control of injectable antibiotic formulations.
• For in-vitro microbiological research, including studies on bacterial susceptibility, minimum inhibitory concentration (MIC) determination, and mechanism of action against Gram-negative bacteria.
• In the synthesis of novel antibiotic derivatives and prodrugs aimed at enhancing pharmacokinetic properties or overcoming bacterial resistance.
• As a critical reagent in biochemical assays to study the interaction between β-lactam antibiotics and penicillin-binding proteins (PBPs).
• Used within quality control laboratories for analytical method development and validation, including HPLC and spectroscopic analyses.

Basic Information

Product Name	Aztreonam
CAS No.	78110-38-0
Molecular Formula	C13H17N5O8S2
Molecular Weight	435.43 g/mol
Synonyms	Azactam; SQ 26,776; (Z)-2-[[[(2-Amino-4-thiazolyl)[[(2S,3S)-2-methyl-4-oxo-1-sulfo-3-azetidinyl]carbamoyl]methylene]amino]oxy]-2-methylpropionic acid; Monobactam antibiotic; Azthreonam; Azreonam; 3-(((Z)-(1-(2-Amino-4-thiazolyl)-2-(((2S,3S)-2-methyl-4-oxo-1-sulfo-3-azetidinyl)amino)-2-oxoethylidene)amino)oxy)-2-methylpropanoic acid
EINECS	Contact for details

Quality Control

Our Aztreonam is produced and tested under a strict quality management system. Each batch is analyzed to meet high-purity standards suitable for pharmaceutical research and development. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles. Specifications can be aligned with relevant pharmacopeial standards (e.g., USP, EP) upon request to ensure regulatory compliance for your specific application.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Specific Optical Rotation	-55° to -65° (c=1 in water)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.