Description

2-Chloro-11-[4-[2-(4-Fluorophenyl)Ethyl]Piperazino]-10,11-Dihydrodibenzo[B,F]Thiepin is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is valued for its role as a key synthetic precursor in the development of active pharmaceutical ingredients (APIs), particularly within the central nervous system (CNS) therapeutic area. It is essential for pharmaceutical manufacturers, R&D laboratories, and fine chemical synthesis companies engaged in the production of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of complex drug molecules, especially psychotropic and neuroactive compounds.
• Research & Development: Serves as a key starting material (KSM) or intermediate in medicinal chemistry programs for developing new chemical entities (NCEs).
• Active Pharmaceutical Ingredient (API) Synthesis: Integral in multi-step synthetic routes for the production of final drug substances targeting specific receptors.
• Reference Standard: Used as a high-purity analytical standard for quality control, method development, and regulatory submissions in pharmaceutical analysis.
• Preclinical Studies: Employed in pharmacological and toxicological studies to understand structure-activity relationships (SAR).
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP-compliant production of clinical trial materials and commercial APIs.

Basic Information

Product Name	2-Chloro-11-[4-[2-(4-Fluorophenyl)Ethyl]Piperazino]-10,11-Dihydrodibenzo[B,F]Thiepin
CAS No.	77602-97-2
Molecular Formula	C26H26ClFN2S
Molecular Weight	452.02 g/mol
Synonyms	2-Chloro-11-[4-[2-(4-fluorophenyl)ethyl]-1-piperazinyl]dibenzo[b,f]thiepin; 2-Chloro-11-(4-(2-(4-fluorophenyl)ethyl)piperazin-1-yl)-10,11-dihydrodibenzo[b,f]thiepin; Zotepine Impurity; Zotepine Intermediate; Zotepine Related Compound; Dibenzo[b,f]thiepin, 2-chloro-11-[4-[2-(4-fluorophenyl)ethyl]-1-piperazinyl]-10,11-dihydro-; 77602-97-2
EINECS	Contact for details

Quality Control

Our 2-Chloro-11-[4-[2-(4-Fluorophenyl)Ethyl]Piperazino]-10,11-Dihydrodibenzo[B,F]Thiepin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques like HPLC, GC, and NMR. We support compliance with ICH guidelines and can supply material suitable for use in cGMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and stored in the original packaging away from direct light and moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.