Description

3A,8,10A-Trihydroxy-5-(Hydroxymethyl)-2,10-Dimethyl-4,6A,7,8,9,10,10A, 10B-Octahydrobenzo[E]Azulen-3(3Ah)-One is a complex polyhydroxylated azulene derivative, a high-value intermediate prized for its intricate molecular scaffold. This compound matters for its role as a critical building block in advanced organic synthesis, particularly for the development of novel pharmaceuticals and bioactive molecules. It is primarily needed by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of complex natural product analogs.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for complex target molecules.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Natural Product Synthesis: An important precursor for the total or semi-synthesis of complex natural products with azulene or polycyclic frameworks.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of high-value fine chemicals.
• Biochemical Research: Potential use as a probe or inhibitor in enzymatic studies due to its specific hydroxylation pattern and stereochemistry.
• Advanced Material Precursor: Exploration into novel organic electronic materials or ligands for catalysis, leveraging its unique conjugated system.

Basic Information

Product Name	3A,8,10A-Trihydroxy-5-(Hydroxymethyl)-2,10-Dimethyl-4,6A,7,8,9,10,10A, 10B-Octahydrobenzo[E]Azulen-3(3Ah)-One
CAS No.	77573-30-9
Molecular Formula	C17H26O5
Molecular Weight	310.39 g/mol
Synonyms	Benzo[e]azulen-3(3aH)-one, 3a,8,10a-trihydroxy-5-(hydroxymethyl)-2,10-dimethyl-4,6a,7,8,9,10,10a,10b-octahydro-; (3aS,5R,6aR,8R,10aR,10bS)-3a,8,10a-Trihydroxy-5-(hydroxymethyl)-2,10-dimethyl-3a,4,6a,7,8,9,10,10a,10b-octahydrobenzo[e]azulen-3(3aH)-one; Polyhydroxylated Azulene Derivative; Azulene Synthon
EINECS	Contact for details

Quality Control

Our 3A,8,10A-Trihydroxy-5-(Hydroxymethyl)-2,10-Dimethyl-4,6A,7,8,9,10,10A, 10B-Octahydrobenzo[E]Azulen-3(3Ah)-One is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity	≥ 98.0% ee
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.