Description

4,9,9A-Tris(Acetyloxy)-3-[(Acetyloxy)Methyl]-1,1A,1B,4,4A,7A,7B,8,9,9A-Decahydro-4A,7B-Dihydroxy-1,1,6,8-Tetramethyl-5H-Cyclopropa[3,4]Benz[1,2-E]Azulen-5-One is a complex, multi-functional diterpenoid derivative with significant potential as a key synthetic intermediate. Its intricate polycyclic structure, featuring multiple acetylated hydroxyl groups, makes it a valuable scaffold for advanced organic synthesis and pharmaceutical research. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a critical building block for the synthesis of novel drug candidates, particularly in oncology and anti-inflammatory research.
• Advanced Organic Synthesis: Used as a complex starting material or intermediate for constructing intricate natural product analogs and complex molecular architectures.
• Agrochemical Research: Investigated as a precursor for developing new plant growth regulators or pesticides with unique modes of action.
• Chemical Biology Probe Development: Utilized to create molecular tools for studying biological pathways and protein interactions.
• Academic & Institutional Research: Employed in university and government labs for methodological studies in total synthesis and stereochemistry.
• Fine Chemical Production: Acts as a specialty intermediate for the manufacture of high-value, low-volume chemicals for niche markets.

Basic Information

Product Name	4,9,9A-Tris(Acetyloxy)-3-[(Acetyloxy)Methyl]-1,1A,1B,4,4A,7A,7B,8,9,9A-Decahydro-4A,7B-Dihydroxy-1,1,6,8-Tetramethyl-5H-Cyclopropa[3,4]Benz[1,2-E]Azulen-5-One
CAS No.	77573-16-1
Molecular Formula	C28H38O10
Molecular Weight	534.60 g/mol
Synonyms	5H-Cyclopropa[3,4]benz[1,2-e]azulen-5-one, 4,9,9a-tris(acetyloxy)-3-[(acetyloxy)methyl]-1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-1,1,6,8-tetramethyl-; 4a,7b-Diacetoxy-3-acetoxymethyl-1,1,6,8-tetramethyl-1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-4,9,9a-triacetoxy-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one; Andrographolide tetraacetate (common name); 3,19-Diacetyl-14-deoxy-12-senecioyl-andrographolide derivative; Neoandrographolide tetraacetate analog; Diterpenoid lactone tetraacetate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and Mass Spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP standards for pharmaceutical applications and can tailor purity grades to meet specific research or development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and potential degradation. Recommended long-term storage temperature is 2°C to 8°C (refrigerated). For short-term use, storage at controlled room temperature (15°C to 25°C) is acceptable.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.