Description

(3Ar)-3,3Aβ,4,5,6,6Aβ,9Aβ,9Bα-Octahydro-4β-Hydroxy-9-Hydroxymethyl-6α-Methyl-3-Methyleneazuleno[4,5-B]Furan-2,7-Dione is a complex sesquiterpene lactone derivative with a fused azulene-furan structure, offering unique chemical reactivity and biological potential. This compound serves as a high-value synthetic intermediate and a scaffold for advanced research in medicinal chemistry. It is primarily sought by pharmaceutical R&D and fine chemical synthesis teams for developing novel therapeutic agents and exploring new chemical spaces.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates with potential anti-inflammatory or anti-cancer activity.
• Medicinal Chemistry Research: Core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Natural Product Synthesis: Advanced intermediate in the total or semi-synthesis of complex sesquiterpenoid natural products.
• Chemical Biology Probes: Used to develop molecular probes for studying biological pathways and target engagement.
• Fine Chemical Production: Serves as a precursor for specialized, high-value chemicals used in advanced material science.
• Academic & Institutional Research: Fundamental studies in organic synthesis methodologies and reaction mechanisms.

Basic Information

Product Name	(3Ar)-3,3Aβ,4,5,6,6Aβ,9Aβ,9Bα-Octahydro-4β-Hydroxy-9-Hydroxymethyl-6α-Methyl-3-Methyleneazuleno[4,5-B]Furan-2,7-Dione
CAS No.	77353-82-3
Molecular Formula	C15H18O5
Molecular Weight	278.30 g/mol
Synonyms	4β-Hydroxy-9-hydroxymethyl-6α-methyl-3-methylenazuleno[4,5-b]furan-2,7-dione; 3-Methyleneazuleno[4,5-b]furan-2,7-dione derivative; Parthenolide analog; Sesquiterpene lactone intermediate; Azulenofurandione; (3aR,4S,6R,6aR,9R,9aS,9bR)-4-Hydroxy-9-(hydroxymethyl)-6-methyl-3-methylidene-3a,4,5,6,6a,9,9a,9b-octahydroazuleno[4,5-b]furan-2,7-dione
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and purity for critical research and development applications. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.