Description

1-Boc-4-Cyanomethyl Piperazine is a versatile and high-purity Boc-protected piperazine derivative, essential for advanced organic synthesis and pharmaceutical research. Its primary value lies in serving as a critical building block for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and fine chemicals. This compound is specifically needed by research scientists and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in medicinal chemistry and custom synthesis.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound libraries.
• Peptidomimetic Chemistry: Used to introduce the piperazine moiety with a protected amine and a functionalizable cyanomethyl handle for constructing peptide-like structures.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Agrochemical Research: Employed in the development of new herbicides and fungicides where the piperazine scaffold is a desired structural feature.
• Custom Chemical Synthesis: Utilized by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects on behalf of clients.
• Polymer Modification: Acts as a functional monomer or cross-linking agent in the synthesis of specialty polymers with tailored properties.

Basic Information

Product Name	1-Boc-4-Cyanomethyl Piperazine
CAS No.	77290-31-4
Molecular Formula	C11H19N3O2
Molecular Weight	225.29 g/mol
Synonyms	1-Boc-4-(Cyanomethyl)piperazine; tert-Butyl 4-(Cyanomethyl)piperazine-1-carboxylate; 4-(Cyanomethyl)-1-piperazinecarboxylic Acid 1,1-Dimethylethyl Ester; 1-(tert-Butoxycarbonyl)-4-(cyanomethyl)piperazine; N-Boc-4-(Cyanomethyl)piperazine; Piperazine, 4-(cyanomethyl)-, 1-(1,1-dimethylethyl) ester; Boc-4-Cyanomethylpiperazine
EINECS	Contact for details

Quality Control

Our 1-Boc-4-Cyanomethyl Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.