Description

tert-Butyl 4-(4-Chlorobenzyl)Piperazine-1-Carboxylate is a high-purity, versatile piperazine derivative and a key protected intermediate in advanced organic synthesis. This compound is critical for researchers and manufacturers requiring precise molecular scaffolds for the development of novel active pharmaceutical ingredients (APIs) and other fine chemicals. It is primarily utilized by the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules, particularly in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new pharmacologically active compounds.
• Process Chemistry & Scale-Up: Serves as a protected intermediate in the development and optimization of scalable synthetic routes for active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Employed as a precursor in the manufacture of advanced pesticides and herbicides, leveraging its piperazine core.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects and contract research organizations (CROs/CMOs) producing specialized fine chemicals.
• Chemical Reference Standard: Used as a high-purity analytical standard for quality control and regulatory compliance in pharmaceutical manufacturing.

Basic Information

Product Name	tert-Butyl 4-(4-Chlorobenzyl)Piperazine-1-Carboxylate
CAS No.	77290-30-3
Molecular Formula	C16H23ClN2O2
Molecular Weight	310.82 g/mol
Synonyms	1-Boc-4-(4-Chlorobenzyl)piperazine; tert-Butyl 4-[(4-Chlorophenyl)methyl]piperazine-1-carboxylate; 4-(4-Chlorobenzyl)piperazine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-(4-chlorobenzyl)piperazine; N-Boc-4-(4-Chlorobenzyl)piperazine; BOC-4-(4-Chlorobenzyl)piperazine; Piperazine, 1-[(1,1-dimethylethoxy)carbonyl]-4-[(4-chlorophenyl)methyl]-
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(4-Chlorobenzyl)Piperazine-1-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.