Description

tert-Butyl 4-(Thiophen-2-Ylmethyl)Piperazine-1-Carboxylate is a high-purity, protected piperazine derivative that serves as a critical building block in advanced organic synthesis. Its value lies in providing a versatile and reactive scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This intermediate is essential for medicinal chemists and process development scientists working on new active pharmaceutical ingredients (APIs), especially in therapeutic areas targeting the central nervous system and other disease modalities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those containing piperazine and thiophene pharmacophores.
• Medicinal Chemistry Research: Used extensively in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Process Chemistry & Scale-up: Serves as a defined starting material for the development and optimization of scalable synthetic routes to target molecules.
• Ligand & Catalyst Development: Employed in the creation of specialized ligands and organocatalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A fundamental building block supplied to CDMOs and research organizations for custom synthesis projects.

Basic Information

Product Name	tert-Butyl 4-(Thiophen-2-Ylmethyl)Piperazine-1-Carboxylate
CAS No.	77278-68-3
Molecular Formula	C14H22N2O2S
Molecular Weight	282.40 g/mol
Synonyms	1-Boc-4-(2-Thienylmethyl)piperazine; 1-(tert-Butoxycarbonyl)-4-(thiophen-2-ylmethyl)piperazine; tert-Butyl 4-[(thiophen-2-yl)methyl]piperazine-1-carboxylate; 4-(Thiophen-2-ylmethyl)piperazine-1-carboxylic acid tert-butyl ester; N-Boc-4-(2-thienylmethyl)piperazine; 77278-68-3; BOC-4-(2-Thienylmethyl)piperazine
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 4-(Thiophen-2-Ylmethyl)Piperazine-1-Carboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. All material is characterized by modern analytical techniques including NMR, HPLC, and MS to confirm identity and purity. Certificates of Analysis (COA) detailing specific lot results are provided with every shipment, and we support customer audits and regulatory documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.