Description

tert-Butyl 4-(2,2,2-trifluoroacetyl)piperazine-1-carboxylate is a high-value, protected piperazine derivative featuring both a Boc (tert-butoxycarbonyl) protecting group and a trifluoroacetyl moiety. This compound is a critical pharmaceutical intermediate and versatile building block in organic synthesis, prized for its role in constructing complex molecules. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology drugs.
• Protease Inhibitor Synthesis: Used in the research and production of protease inhibitors, which are vital for treating viral infections like HIV and Hepatitis C.
• Agrochemical Development: Serves as a precursor in creating novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Chemical Biology & Medicinal Chemistry: Employed in drug discovery programs for structure-activity relationship (SAR) studies and lead optimization.
• Peptidomimetic Synthesis: Integral for constructing peptidomimetics, which are molecules that mimic peptides but with improved stability and bioavailability.
• Ligand & Catalyst Development: Used to create specialized ligands and organocatalysts for asymmetric synthesis.

Basic Information

Product Name	tert-Butyl 4-(2,2,2-Trifluoroacetyl)Piperazine-1-Carboxylate
CAS No.	77278-37-6
Molecular Formula	C11H17F3N2O3
Molecular Weight	282.26 g/mol
Synonyms	1-Boc-4-(Trifluoroacetyl)piperazine; 1-(tert-Butoxycarbonyl)-4-(trifluoroacetyl)piperazine; tert-Butyl 4-(trifluoroacetyl)-1-piperazinecarboxylate; 4-(Trifluoroacetyl)piperazine-1-carboxylic acid tert-butyl ester; N-Boc-4-(trifluoroacetyl)piperazine; 1-N-Boc-4-N-trifluoroacetylpiperazine; 77278-37-6; Boc-piperazine-trifluoroacetamide
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(2,2,2-trifluoroacetyl)piperazine-1-carboxylate is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent quality suitable for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if frequent access is required.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.