Description

1-Cyclopropylpiperazine-4-Carboxylic Acid tert-Butyl Ester CAS NO 77278-34-3 is a high-value, protected piperazine derivative serving as a critical building block in advanced organic synthesis. Its core value lies in providing a versatile and reactive scaffold for constructing complex nitrogen-containing heterocycles, which are central to modern drug discovery. This compound is essential for medicinal chemistry researchers and process development scientists in the pharmaceutical and agrochemical industries, where it is used to develop novel active pharmaceutical ingredients (APIs) and crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of small molecule drug candidates, particularly those targeting central nervous system (CNS) disorders, infectious diseases, and oncology.
• Medicinal Chemistry Scaffold: Used to explore structure-activity relationships (SAR) by introducing diverse substituents onto the piperazine and cyclopropyl rings.
• Agrochemical Synthesis: Serves as a building block for developing novel herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Chemical Biology Probe Development: Utilized in the creation of tool compounds and molecular probes for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects and the scale-up of complex molecules under cGMP or research-grade conditions.

Basic Information

Product Name	1-Cyclopropylpiperazine-4-Carboxylic Acid tert-Butyl Ester
CAS No.	77278-34-3
Molecular Formula	C12H22N2O2
Molecular Weight	226.32 g/mol
Synonyms	tert-Butyl 1-cyclopropylpiperazine-4-carboxylate; 1-Cyclopropyl-4-(tert-butoxycarbonyl)piperazine; 4-Boc-1-cyclopropylpiperazine; N-Boc-1-cyclopropylpiperazine; 1-Cyclopropylpiperazine-4-carboxylic acid 1,1-dimethylethyl ester; 1-Cyclopropyl-4-piperazinecarboxylic acid tert-butyl ester; 1-Cyclopropyl-4-(tert-butoxycarbonyl)piperazine; 1-Cyclopropylpiperazine-4-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 1-Cyclopropylpiperazine-4-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to confirm identity, purity, and impurity profiles. We provide detailed Certificates of Analysis (COA) with every shipment, and our quality systems support development from research-grade to cGMP-compliant material for advanced clinical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.