Description

(2E)-3-(4-Ethoxyphenyl)Acryloyl Chloride is a high-purity, reactive organic intermediate belonging to the class of cinnamoyl chlorides. This compound is a critical building block in advanced organic synthesis, valued for its ability to introduce the (E)-4-ethoxycinnamoyl moiety into target molecules. It is primarily sought after by research and development teams and production chemists in the pharmaceutical and agrochemical industries for the synthesis of active pharmaceutical ingredients (APIs), fine chemicals, and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in therapeutic areas requiring cinnamic acid derivatives.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where the 4-ethoxyphenyl group confers specific biological activity.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing organic semiconductors and liquid crystal compounds for display technologies.
• Polymer Modification: Employed to functionalize polymers through reactions with hydroxyl or amine groups, imparting new material properties.
• Peptide & Protein Conjugation: Acts as an acylating agent for modifying biomolecules in biochemical research and bioconjugate development.
• Organic Synthesis Reagent: A versatile reagent for Friedel-Crafts acylation, amide coupling, and esterification reactions under mild conditions.

Basic Information

Product Name	(2E)-3-(4-Ethoxyphenyl)Acryloyl Chloride
CAS No.	77251-75-3
Molecular Formula	C11H11ClO2
Molecular Weight	210.66 g/mol
Synonyms	(E)-3-(4-Ethoxyphenyl)acryloyl chloride; trans-4-Ethoxycinnamoyl chloride; (E)-4-Ethoxycinnamoyl chloride; 4-Ethoxy-trans-cinnamoyl chloride; 3-(4-Ethoxyphenyl)-2-propenoyl chloride, (E)-; p-Ethoxycinnamic acid chloride; 2-Propenoyl chloride, 3-(4-ethoxyphenyl)-, (2E)-; 77251-75-3
EINECS	Contact for details

Quality Control

Our (2E)-3-(4-Ethoxyphenyl)Acryloyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and FTIR, to ensure high chemical purity and structural identity. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade intermediates and research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.