Description

Leukotriene D3 CAS NO 77165-74-3 is a potent bioactive lipid mediator belonging to the cysteinyl leukotriene family, derived from the 5-lipoxygenase pathway of arachidonic acid metabolism. This compound is of significant interest for its role as a key signaling molecule in inflammatory and allergic responses, particularly in the respiratory system. It is primarily utilized by researchers and pharmaceutical developers in the fields of immunology, pharmacology, and respiratory disease research to study pathophysiological mechanisms and screen potential therapeutic agents.

Application

• Biomedical Research: Used as a critical reference standard and bioactive agent in studies of inflammation, asthma, and allergic reactions.
• Pharmacological Screening: Serves as a target molecule in high-throughput assays to identify and evaluate novel leukotriene receptor antagonists.
• Drug Discovery & Development: Employed in the synthesis and testing of new anti-inflammatory and anti-asthma drug candidates.
• Clinical Diagnostics: Acts as a calibration standard in analytical methods (e.g., LC-MS/MS) for quantifying leukotriene levels in biological samples.
• Biochemical Pathway Analysis: Essential for in vitro and in vivo studies mapping the arachidonic acid cascade and eicosanoid signaling networks.
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental studies in immunology and cell biology.

Basic Information

Product Name	Leukotriene D3
CAS No.	77165-74-3
Molecular Formula	C25H39NO6S
Molecular Weight	481.65 g/mol
Synonyms	LTD3; (5S,6R)-7-[(1R,2E,4E,6Z,9Z)-1-[(2S)-2-Amino-2-carboxyethyl]sulfanyl-2,4,6,9-heptadecatetraen-1-yl]-5,6-epoxyoxepan-2-one; 5(S),6(R)-LTD3; Leukotriene D3; cis-5,6-LTD3
EINECS	Contact for details

Quality Control

Our Leukotriene D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. Keep the container in a dry, cool, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Solubility	Soluble in ethanol, DMSO; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.