Description

Monacolin J is a key intermediate compound in the biosynthesis of cholesterol-lowering statins, including lovastatin. Its precise chemical structure makes it a critical building block for pharmaceutical research and development, particularly in the synthesis and study of HMG-CoA reductase inhibitors. This high-purity intermediate is essential for manufacturers and research institutions focused on cardiovascular drug development, metabolic disorder studies, and advanced synthetic chemistry.

Application

• Pharmaceutical Intermediate: Primary use as a crucial precursor in the synthesis of statin drugs like lovastatin and simvastatin.
• Biochemical Research: Used as a reference standard and tool compound in studies of cholesterol biosynthesis and HMG-CoA reductase enzyme activity.
• Process Development: Employed in the development and optimization of fermentation and synthetic routes for statin production.
• Analytical Standard: Serves as a high-purity standard for HPLC, LC-MS, and other analytical methods to quantify statins and related metabolites.
• Academic Research: Utilized in university and institutional labs for investigating fungal metabolism and polyketide synthesis pathways.

Basic Information

Product Name	Monacolin J
CAS No.	76343-78-7
Molecular Formula	C24H36O5
Molecular Weight	404.54 g/mol
Synonyms	Monacolin J; (4R,6R)-6-[(1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-Hexahydro-6-hydroxy-8-[(2S)-2-methylbutyryloxy]-2-methyl-1-naphthalenyl]-4-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one; L-154,803; ML-236B sodium salt derivative; Dihydromonacolin L precursor
EINECS	Contact for details

Quality Control

Our Monacolin J is produced under strict quality management systems to ensure high purity and batch-to-batch consistency. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP guidelines for pharmaceutical intermediates, and specifications can be aligned with client requirements for research or commercial use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.