Description

Benzoyl Chloride, 2-Chloro-4-(Trifluoromethyl)- is a versatile trifluoromethylated benzoyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the unique combination of the reactive acid chloride group and the electron-withdrawing trifluoromethyl and chloro substituents, which enable precise molecular modifications. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality raw materials for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing the trifluoromethyl group to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in manufacturing advanced herbicides, fungicides, and insecticides where the trifluoromethyl moiety improves efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a building block for creating fluorinated aromatic compounds used in electronic display technologies.
• Polymer & Resin Modifier: Incorporated to introduce fluorinated aromatic units into polymer chains, altering properties like chemical resistance, thermal stability, and surface characteristics.
• Dye & Pigment Manufacturing: Intermediate for producing specialized fluorinated dyes and pigments with unique color fastness and optical properties.
• Organic Synthesis Reagent: Employed in Friedel-Crafts acylation and other reactions to introduce the 2-chloro-4-(trifluoromethyl)benzoyl moiety into target molecules.

Basic Information

Item	Details
Product Name	Benzoyl Chloride, 2-Chloro-4-(Trifluoromethyl)-
CAS No.	76286-03-8
Molecular Formula	C8H3Cl2F3O
Molecular Weight	243.01 g/mol
Synonyms	2-Chloro-4-(trifluoromethyl)benzoyl chloride; 2-Chloro-α,α,α-trifluoro-p-toluoyl chloride; 4-(Trifluoromethyl)-2-chlorobenzoyl chloride; 2-Chloro-4-trifluoromethylbenzoyl chloride; α,α,α-Trifluoro-2-chloro-4-methylbenzoyl chloride; 2-Chloro-α,α,α-trifluoro-4-methylbenzoyl chloride; Benzoyl chloride, 2-chloro-4-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our production of Benzoyl Chloride, 2-Chloro-4-(Trifluoromethyl)- adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for critical B2B applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications. We support compliance with REACH, FDA guidelines for drug intermediates, and other global regulatory frameworks as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and a strong acid/organic solvent; ensure containers are kept tightly sealed to exclude moisture and away from incompatible materials such as strong bases, amines, and oxidizing agents. Due to its highly volatile nature, handle and store in a fume hood or adequately ventilated environment.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Density (at 20°C)	~1.5 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.