Description

5'-Hydroxypiroxicam is a key pharmaceutical intermediate and metabolite of the non-steroidal anti-inflammatory drug (NSAID) piroxicam. This compound is of significant importance for research and development in medicinal chemistry, particularly in studies related to drug metabolism, pharmacokinetics, and the synthesis of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, analytical reference standard suppliers, and manufacturers engaged in the production of advanced anti-inflammatory medications.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis and research of piroxicam analogs and related NSAIDs.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical studies to understand the metabolic pathway and pharmacokinetics of piroxicam.
• Medicinal Chemistry Research: Serves as a precursor for the development of new chemical entities with potential anti-inflammatory, analgesic, or antipyretic properties.
• Quality Control & Analytical Testing: Employed in HPLC, LC-MS, and other chromatographic methods for method development, validation, and impurity profiling in pharmaceutical quality assurance.
• Biochemical Research: Used in in-vitro and in-vivo studies to investigate the mechanism of action and side-effect profiles of COX inhibitors.

Basic Information

Product Name	5'-Hydroxypiroxicam
CAS No.	76066-11-0
Molecular Formula	C15H13N3O5S
Molecular Weight	347.35 g/mol
Synonyms	5'-Hydroxy Piroxicam; 4-Hydroxy-2-methyl-N-(5-hydroxy-2-pyridinyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide; Piroxicam 5'-Hydroxy Metabolite; 5'-OH-Piroxicam; 5-Hydroxypiroxicam; 5'-Hydroxy Piroxicam (Piroxicam Impurity); Piroxicam Related Compound B; 5'-OHPX
EINECS	Contact for details

Quality Control

Our 5'-Hydroxypiroxicam is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via advanced techniques like HPLC and mass spectrometry, to ensure it meets high-purity standards suitable for pharmaceutical research. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.