Description

4-Methyl-Piperazine-2-Carboxylic Acid Dihydrochloride is a high-purity, pharmaceutically relevant building block and chiral intermediate. This compound is critical for the synthesis of complex molecules, offering a defined stereocenter and functional handles for further derivatization. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly in areas like enzyme inhibitors and receptor modulators.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for central nervous system (CNS) and anti-infective therapies.
• Peptide Mimetic Synthesis: Used to incorporate constrained piperazine carboxylic acid motifs into peptide backbones to enhance metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands used in asymmetric catalysis and metal complexation.
• Chemical Biology Research: Employed in the design and synthesis of molecular probes and tool compounds for studying biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production of client-specific molecules.

Basic Information

Product Name	4-Methyl-Piperazine-2-Carboxylic Acid Dihydrochloride
CAS No.	75944-99-9
Molecular Formula	C7H14N2O2 · 2HCl
Molecular Weight	239.12 g/mol
Synonyms	(2S)-4-Methylpiperazine-2-carboxylic acid dihydrochloride; (S)-4-Methylpiperazine-2-carboxylic acid dihydrochloride; L-4-Methylpiperazine-2-carboxylic acid dihydrochloride; 4-Methyl-2-piperazinecarboxylic acid dihydrochloride; 2-Piperazinecarboxylic acid, 4-methyl-, dihydrochloride, (2S)-; 75944-99-9
EINECS	Contact for details

Quality Control

Our 4-Methyl-Piperazine-2-Carboxylic Acid Dihydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D and pre-clinical development. A detailed Certificate of Analysis (COA) providing HPLC purity, chiral purity, water content (KF), and residual solvent data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.