Description

11-Trans Leukotriene E4 CAS NO 75715-88-7 is a specialized eicosanoid metabolite, specifically a cysteinyl leukotriene, of significant interest in biochemical and pharmacological research. This compound serves as a critical reference standard and analytical tool for investigating the leukotriene pathway and its role in inflammatory and allergic responses. It is essential for researchers and quality control laboratories in the pharmaceutical, biotechnology, and diagnostic sectors who require high-purity biochemicals for method development, validation, and advanced studies.

Application

• Biochemical Research Standard: Used as a high-purity reference material in studies of arachidonic acid metabolism and leukotriene biosynthesis pathways.
• Pharmaceutical R&D: Critical for the development and screening of novel therapeutics targeting asthma, allergic rhinitis, and other inflammatory diseases mediated by cysteinyl leukotrienes.
• Diagnostic Assay Development: Employed as a calibrator and control in the development of immunoassays (e.g., ELISA) and LC-MS/MS methods for quantifying leukotriene levels in biological samples.
• Metabolomics & Biomarker Discovery: A key analyte in metabolomic profiling to understand disease mechanisms and identify potential biomarkers related to inflammation.
• Academic Research: Supports fundamental research in cell biology, immunology, and physiology to elucidate the role of leukotrienes in cellular signaling.
• Quality Control: Serves as an impurity marker or system suitability standard in the quality control of related pharmaceutical compounds.

Basic Information

Product Name	11-Trans Leukotriene E4
CAS No.	75715-88-7
Molecular Formula	C23H37NO7S
Molecular Weight	471.61 g/mol
Synonyms	(11E)-Leukotriene E4; 11-trans-LTE4; 11-trans-LTE4; 5(S),6(R)-Dihydroxy-7,9,11,14-eicosatetraenoic acid, cysteine conjugate, (11E)-isomer; 11-E-Leukotriene E4; LTE4 (11-trans isomer); (11E)-LTE4; 11-trans-5(S),6(R)-Dihydroxy-7,9-trans-11,14-cis-eicosatetraenoyl-L-cysteine
EINECS	Contact for details

Quality Control

Every batch of 11-Trans Leukotriene E4 is manufactured and analyzed under strict quality management systems. We employ advanced analytical techniques, including HPLC and mass spectrometry, to ensure identity, purity, and stability. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and chromatographic profiles is provided with each shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and easily oxidized; therefore, containers should be allowed to equilibrate to room temperature before opening to minimize moisture ingress, and handling should be performed under anhydrous conditions when possible.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.