Description

Glycocholic Acid 3-o-β-Glucuronide Disodium Salt is a high-purity, conjugated bile acid derivative, specifically the 3-O-glucuronide of glycocholic acid. This compound is a critical biochemical standard and reagent for advanced research in hepatobiliary physiology and drug metabolism studies. It is primarily utilized by pharmaceutical R&D laboratories, diagnostic manufacturers, and academic institutions focused on liver function, cholestasis, and the enterohepatic circulation.

Application

• Biochemical Research Standard: Serves as a primary reference standard for the quantification and identification of bile acid glucuronides in biological matrices.
• Diagnostic Kit Development: Used in the formulation and calibration of enzymatic and immunoassay kits for liver function and cholestatic disease markers.
• Drug Metabolism & Pharmacokinetics (DMPK): Employed in studies investigating Phase II metabolism (glucuronidation) and the biliary excretion pathways of drug candidates.
• Toxicology Studies: Applied in research models to understand hepatotoxicity and the role of specific bile acid conjugates in liver injury.
• Cell Culture & In Vitro Studies: Used as a defined component in media for hepatocyte and cholangiocyte culture systems to study bile acid transport and signaling.

Basic Information

Product Name	Glycocholic Acid 3-o-β-Glucuronide Disodium Salt
CAS No.	75672-42-3
Molecular Formula	C32H49NNa2O13
Molecular Weight	701.71 g/mol
Synonyms	Glycocholic Acid 3-O-β-D-Glucuronide Disodium Salt; 3-O-(β-D-Glucopyranosyluronic acid)-N-[(3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]glycine Disodium Salt; Disodium Glycocholate 3-O-Glucuronide; Taurocholic Acid 3-O-Glucuronide Analog; Bile Acid 3-O-Glucuronide Standard; GCA-3-GlcA; 3-Glucuronyl-glycocholate Disodium Salt
EINECS	Contact for details

Quality Control

Our Glycocholic Acid 3-o-β-Glucuronide Disodium Salt is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for research and diagnostic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming batch-specific purity, identity, and safety data.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.