Description

Glycoursodeoxycholic Acid-3-o-β-Glucuronide Disodium Salt is a high-purity, conjugated bile acid derivative, specifically the 3-O-β-glucuronide of glycoursodeoxycholic acid. This compound is of significant interest in advanced pharmaceutical research and development, particularly for its role as a key metabolite and potential therapeutic agent. It is primarily utilized by research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in hepatology, metabolic disease studies, and the synthesis of novel drug candidates.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantification and qualification of bile acid metabolites in bioanalytical methods, including LC-MS/MS.
• Metabolite Research: Critical for studying the metabolic pathways, pharmacokinetics, and detoxification mechanisms of ursodeoxycholic acid (UDCA) and its derivatives.
• Drug Discovery & Development: Used as a key intermediate or active pharmaceutical ingredient (API) in the development of novel therapeutics targeting liver diseases, cholestasis, and metabolic disorders.
• Biochemical Assays: Employed in in vitro and cell-based assays to investigate bile acid signaling, receptor activation (e.g., FXR, TGR5), and cellular transport mechanisms.
• Diagnostic Kit Manufacturing: Incorporated into ELISA kits and other diagnostic reagents for the precise measurement of conjugated bile acids in clinical and research settings.

Basic Information

Item	Detail
Product Name	Glycoursodeoxycholic Acid-3-o-β-Glucuronide Disodium Salt
CAS No.	75672-31-0
Molecular Formula	C32H51NNa2O11
Molecular Weight	671.73 g/mol
Synonyms	GUDCA-3-Glucuronide Disodium Salt; 3-O-(β-D-Glucopyranosyluronic acid)-N-[(3α,5β,7β)-3,7-dihydroxy-24-oxocholan-24-yl]glycine Disodium Salt; Glycoursodeoxycholic Acid 3-O-β-D-Glucuronide Disodium; Ursodeoxycholic Acid Glucuronide Derivative; Sodium Glycoursodeoxycholate-3-glucuronide; 3-GUDCA-Glucuronide Na2; N-[(3α,5β,7β)-3,7-Dihydroxy-24-oxo-24-[[(2S,3S,4S,5S,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy]cholan-24-yl]glycine Disodium Salt
EINECS	Contact for details

Quality Control

Our Glycoursodeoxycholic Acid-3-o-β-Glucuronide Disodium Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and heavy metals. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade and cGMP standards for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption. For extended storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.