Description

25-Hydroxy-26,26,26,27,27,27-Hexafluorovitamin D3 is a fluorinated analog of the key vitamin D metabolite, 25-hydroxyvitamin D3. This compound matters for its enhanced metabolic stability and unique biological profile, making it a valuable tool for probing vitamin D receptor (VDR) function and metabolic pathways. It is primarily needed by researchers in pharmaceutical development, biochemistry, and endocrinology for use as a reference standard and a critical intermediate in the synthesis of novel vitamin D analogs.

Application

• Pharmaceutical Research & Development: A key intermediate for synthesizing novel fluorinated vitamin D analogs with potential therapeutic applications.
• Biochemical Research: Used as a stable, non-natural probe to study the structure-activity relationship (SAR) of the vitamin D endocrine system and VDR binding.
• Reference Standard: Serves as a high-purity analytical standard for method development and quality control in laboratories analyzing vitamin D metabolites.
• Metabolic Studies: Employed to investigate the impact of fluorination on the metabolic stability and biological half-life of vitamin D compounds.
• Endocrinology Research: A tool for exploring calcium homeostasis, bone metabolism, and cell differentiation pathways influenced by modified vitamin D structures.

Basic Information

Product Name	25-Hydroxy-26,26,26,27,27,27-Hexafluorovitamin D3
CAS No.	75303-43-4
Molecular Formula	C₂₇H₃₈F₆O₂
Molecular Weight	508.59 g/mol
Synonyms	1α,25-Dihydroxy-26,26,26,27,27,27-hexafluorovitamin D3 (precursor); 25-Hydroxy-26,27-hexafluorocholecalciferol; (5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-3β,25-diol, 26,26,26,27,27,27-hexafluoro-; Hexafluorinated 25-Hydroxyvitamin D3; 25(OH)D3-Hexafluoro analog; 25-Hydroxy-26,27,27,27,28,28,28-heptafluorovitamin D3 (common misnomer); Falecalcitriol intermediate.
EINECS	Contact for details

Quality Control

Our 25-Hydroxy-26,26,26,27,27,27-Hexafluorovitamin D3 is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets the exacting standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic and spectral data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., argon or nitrogen) at -20°C or below to minimize oxidation and ensure long-term stability. Allow the container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.