Description

14,15-Leukotriene A4 Methyl Ester is a specialized methyl ester derivative of a key leukotriene intermediate. This compound is of significant value in biochemical and pharmaceutical research for studying the biosynthesis and biological activity of leukotriene mediators. It serves as a critical reference standard and synthetic precursor for researchers in immunology, inflammation, and respiratory pharmacology. Target users include pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on eicosanoid signaling pathways.

Application

• Biochemical Research: Used as a reference standard in the study of leukotriene biosynthesis and metabolism pathways.
• Pharmaceutical Development: Serves as a key synthetic intermediate or analytical standard in the development of anti-inflammatory and immunomodulatory drugs.
• Enzymology Studies: Employed as a substrate for investigating the activity and inhibition of enzymes like leukotriene A4 hydrolase.
• Cell Signaling Research: Utilized in cellular assays to probe the role of leukotriene derivatives in inflammatory and allergic responses.
• Analytical Method Development: Acts as a critical calibration standard for developing and validating HPLC, LC-MS, or GC-MS methods for eicosanoid analysis.
• Metabolite Identification: Aids in the identification and quantification of leukotriene metabolites in biological samples.

Basic Information

Product Name	14,15-Leukotriene A4 Methyl Ester
CAS No.	75290-58-3
Molecular Formula	C22H34O3
Molecular Weight	346.51 g/mol
Synonyms	14,15-LTA4 Methyl Ester; Methyl (5S,6S)-5,6-Epoxy-7,9,11,14-eicosatetraenoate; Leukotriene A4 Methyl Ester; 5,6-Epoxy-7,9,11,14-eicosatetraenoic Acid Methyl Ester; LTA4 Methyl Ester; (5S,6S)-5,6-Epoxy-7,9,11,14-eicosatetraenoic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our 14,15-Leukotriene A4 Methyl Ester is produced under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Total Impurities (HPLC)	≤ 5.0%
Solubility	Soluble in ethanol, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.