Description

Phosphonic Acid Bis(Trimethylsilylmethyl) Ester is a specialized organosilicon reagent featuring a phosphonate ester group flanked by two trimethylsilylmethyl moieties. This unique structure makes it a valuable intermediate for the synthesis of novel phosphorus-containing compounds and for use as a silylating agent in organic transformations. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and advanced materials sectors. The compound's reactivity is leveraged in the development of new catalysts, ligands, and functional polymers.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs) and prodrugs, particularly those requiring phosphorus or silicon functionalities.
• Organometallic Catalyst & Ligand Synthesis: Used to prepare specialized phosphonate-based ligands for transition metal catalysts used in cross-coupling and hydrogenation reactions.
• Advanced Material Precursor: Acts as a monomer or cross-linking agent in the development of specialty polymers, resins, and coatings with tailored thermal or surface properties.
• Silylating Agent: Employed in organic synthesis to introduce the trimethylsilylmethyl (CH2SiMe3) protecting group or as a reagent in Horner-Wadsworth-Emmons olefination reactions.
• Agrochemical Research: Utilized in the research and development of new herbicides, plant growth regulators, or other agrochemicals containing phosphonate esters.
• Flame Retardant Additive Development: Investigated as a potential synergist or component in flame-retardant formulations for plastics and textiles due to its phosphorus content.

Basic Information

Product Name	Phosphonic Acid Bis(Trimethylsilylmethyl) Ester
CAS No.	75203-61-1
Molecular Formula	C10H27O3PSi2
Molecular Weight	282.47 g/mol
Synonyms	Bis((trimethylsilyl)methyl) Phosphonate; (Trimethylsilylmethyl) Phosphonate; Di(trimethylsilylmethyl) Phosphonate; Phosphonic Acid, Bis(trimethylsilylmethyl) Ester; Phosphonic Acid Di(trimethylsilylmethyl) Ester; (TMSM)2PO(OR); Bis(trimethylsilylmethyl) Phosphite (common misnomer); O,O-Bis(trimethylsilylmethyl) Hydrogen Phosphonate
EINECS	Contact for details

Quality Control

Our Phosphonic Acid Bis(Trimethylsilylmethyl) Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including NMR (¹H, ¹³C, ³¹P), GC, and HPLC analysis, to confirm identity, purity, and the absence of critical impurities. We provide full traceability and Certificates of Analysis (COA) are available for all shipments. Our quality systems support development and cGMP manufacturing requirements for our pharmaceutical partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.