Description

(1S*,2S*)-Threo-2-(4-Benzylpiperidino)-1-(4-Hydroxyphenyl)-1-Propanolhemitartrate is a high-purity, stereochemically defined organic compound of significant interest in advanced pharmaceutical research and development. This compound serves as a critical chiral intermediate or reference standard for the synthesis and analytical characterization of complex active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists, process development scientists, and quality control laboratories within the pharmaceutical, biotechnology, and fine chemical sectors.

Application

• Pharmaceutical Intermediate: Key chiral building block in the synthesis of novel therapeutic agents, particularly in central nervous system (CNS) and cardiovascular research.
• Reference Standard: Used as a certified reference material (CRM) for method development, validation, and quality control in HPLC, LC-MS, and chiral analysis.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of enantiomerically pure pharmaceuticals.
• Metabolite Studies: Serves as a standard or precursor in the identification and quantification of drug metabolites during ADME (Absorption, Distribution, Metabolism, and Excretion) studies.
• Academic & Contract Research: Utilized in university and CRO (Contract Research Organization) settings for medicinal chemistry programs and pharmacological research.

Basic Information

Product Name	(1S*,2S*)-Threo-2-(4-Benzylpiperidino)-1-(4-Hydroxyphenyl)-1-Propanolhemitartrate
CAS No.	74991-34-7
Molecular Formula	C22H29NO5 • 0.5C4H6O6
Molecular Weight	~452.52 g/mol (hemitartrate salt form)
Synonyms	Threo-2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)-1-propanol hemitartrate; (1S,2S)-2-(4-Benzylpiperidin-1-yl)-1-(4-hydroxyphenyl)propan-1-ol hemihydrate tartrate; 4-Hydroxy-α-[2-(4-benzyl-1-piperidinyl)-1-methylethyl]benzenemethanol hemitartrate; (1S,2S)-Form of Fluoxetine-related intermediate; Rel-(1S,2S)-2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)-1-propanol hydrogen tartrate (1:0.5)
EINECS	Contact for details

Quality Control

Our (1S*,2S*)-Threo-2-(4-Benzylpiperidino)-1-(4-Hydroxyphenyl)-1-Propanolhemitartrate is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥98% by HPLC), chiral excess, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (1S*,2S*) isomer
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.