Description

12-Hydroxy-5,8,10,14,17-Eicospentaenoic Acid is a specialized hydroxylated derivative of eicosapentaenoic acid (EPA), a key ω-3 fatty acid. This compound is of significant interest in biochemical and pharmaceutical research due to its role as a bioactive lipid mediator involved in inflammatory and resolution pathways. It serves as a critical reference standard and intermediate for researchers and manufacturers in the life sciences sector, particularly for developing analytical methods and studying lipid metabolism.

Application

• Biochemical Research Standard: Used as a high-purity reference material for the identification and quantification of oxylipins and specialized pro-resolving mediators (SPMs) in biological samples via LC-MS/MS.
• Pharmaceutical R&D: Acts as a key intermediate or analytical standard in the development of novel therapeutics targeting inflammation, immune modulation, and metabolic disorders.
• Nutritional Science Studies: Employed in research to investigate the metabolic fate and bioactive effects of ω-3 fatty acid derivatives in cellular and animal models.
• Diagnostic Kit Development: Utilized as a calibrator or control in the development of immunoassays or clinical diagnostic tests for lipid mediators.
• Cosmeceutical Research: Investigated for potential applications in advanced skincare formulations targeting inflammatory skin conditions due to its bioactive properties.

Basic Information

Product Name	12-Hydroxy-5,8,10,14,17-Eicospentaenoic Acid
CAS No.	74838-73-6
Molecular Formula	C₂₀H₃₀O₄
Molecular Weight	334.45 g/mol
Synonyms	12-HEPE; 12-Hydroxy-5Z,8Z,10E,14Z,17Z-eicosapentaenoic acid; 12(S)-HEPE; 12-Hydroxyicosapentaenoic acid; 12-Hydroxy-EPA; (5Z,8Z,10E,14Z,17Z)-12-Hydroxyicosa-5,8,10,14,17-pentaenoic acid; 12-Hydroxyeicosapentaenoic Acid
EINECS	Contact for details

Quality Control

Every batch of 12-Hydroxy-5,8,10,14,17-Eicospentaenoic Acid is manufactured and analyzed under strict quality management protocols. We provide comprehensive analytical data to ensure identity, purity, and consistency, meeting the stringent requirements of research and development applications. A detailed Certificate of Analysis (COA) including results from HPLC, MS, and NMR is supplied with each shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store unopened vials at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Store away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Isomeric Purity	≥ 90% (12(S)-isomer)
Solubility	Soluble in ethanol, DMSO; slightly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.