Description

Ciglitazone CAS NO 74772-77-3 is a synthetic thiazolidinedione derivative and a well-characterized peroxisome proliferator-activated receptor gamma (PPARγ) agonist. This compound is a critical research-grade chemical, primarily valued for its role as a reference standard and a key tool in metabolic and pharmacological studies. It is essential for researchers and developers in the pharmaceutical and biotechnology sectors, particularly those focused on diabetes research, insulin sensitization, and nuclear receptor signaling pathways.

Application

• Pharmaceutical Reference Standard: Used as a high-purity analytical standard for quality control and method validation in drug development and manufacturing.
• Biochemical Research: Serves as a potent PPARγ ligand in studies investigating receptor activation, gene expression, and adipocyte differentiation.
• Metabolic Disease Models: Employed in preclinical research to study insulin resistance, glucose homeostasis, and lipid metabolism in cellular and animal models.
• Mechanistic Studies: A vital tool for elucidating the molecular pathways involved in type 2 diabetes and related metabolic syndromes.
• Drug Discovery & Screening: Used in assay development and high-throughput screening to identify and evaluate novel therapeutic agents targeting PPARγ.
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental scientific investigation in endocrinology and pharmacology.

Basic Information

Product Name	Ciglitazone
CAS No.	74772-77-3
Molecular Formula	C₁₈H₂₀N₂O₃S
Molecular Weight	344.43 g/mol
Synonyms	5-{4-[(1-Methylcyclohexyl)methoxy]benzyl}-1,3-thiazolidine-2,4-dione; ADD-3878; U-63287; Ciglitizone; NSC-338993; PPARγ Agonist Ciglitazone; Thiazolidinedione Derivative
EINECS	Contact for details

Quality Control

Our Ciglitazone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to guarantee traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.