Description

Alpha,ω-Bis(2-Carboxyethyl)Polyethylene Glycol 10'000 is a high-purity, heterobifunctional polyethylene glycol derivative featuring a carboxylic acid group at each terminus of a long, hydrophilic PEG spacer. This molecular architecture is critical for creating stable, water-soluble conjugates and functionalized materials. It is an essential building block for researchers and manufacturers in the pharmaceutical and advanced materials sectors who require precise, reliable, and scalable PEGylation chemistry.

Application

• Pharmaceutical PEGylation: A key linker for attaching therapeutic peptides, proteins, and small molecule drugs to PEG chains, enhancing solubility, stability, and circulation half-life.
• Bioconjugation & Cross-linking: Used to create stable amide bonds between biomolecules (e.g., antibodies, enzymes) and other entities like fluorescent dyes, surfaces, or nanoparticles.
• Hydrogel Synthesis: Serves as a water-soluble macromonomer for creating biodegradable and biocompatible hydrogels for drug delivery and tissue engineering applications.
• Surface Functionalization: Enables the covalent attachment of a hydrophilic, non-fouling PEG layer to materials (e.g., medical devices, sensors, chromatography media) to improve biocompatibility.
• Polymer Chemistry: Acts as a macroinitiator or telechelic polymer for synthesizing block copolymers and complex polymer architectures via its reactive carboxyl end groups.
• Diagnostic Reagents: Utilized in the development of diagnostic assays and imaging probes where controlled conjugation and water solubility are paramount.

Basic Information

Item	Detail
Product Name	Alpha,ω-Bis(2-Carboxyethyl)Polyethylene Glycol 10'000
CAS No.	74558-41-1
Molecular Formula	C2n+6H4n+10On+5 (n~227)
Molecular Weight	~10,000 g/mol (nominal)
Synonyms	HOOC-PEG-COOH; Carboxy-PEG-Carboxylic Acid; α,ω-Bis(carboxyethyl) PEG 10k; Dicarboxy-terminated PEG 10,000; PEG 10,000 diacid; Poly(ethylene glycol) bis(carboxymethyl) ether 10k; Polyoxyethylene bis(2-carboxyethyl) ether; 2,2'-(Oxybis(ethane-2,1-diyl))bis(oxy))diacetic acid polyethylene glycol derivative
EINECS	Contact for details

Quality Control

Every batch of our Alpha,ω-Bis(2-Carboxyethyl)Polyethylene Glycol 10'000 is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high standards required for research and cGMP manufacturing. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming critical parameters such as molecular weight distribution, functional group content, and purity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere (argon or nitrogen) is recommended to maintain optimal quality and functionality.

Specification

Item	Specification
Appearance	White to off-white waxy solid or powder
Identification (IR)	Conforms to structure
Average Molecular Weight (GPC)	9,500 - 10,500 g/mol
Polydispersity Index (PDI)	≤ 1.05
Acid Value (Titration)	0.18 - 0.22 meq/g
Water Content (KF)	≤ 1.0 %
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.