Description

2-(3-Trifluoromethyl-Phenyl)-Piperazine is a high-purity, functionalized piperazine derivative, a critical building block in advanced organic synthesis. Its value lies in the trifluoromethylphenyl moiety, which is instrumental in modulating the physicochemical and metabolic properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients with enhanced bioavailability and stability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of central nervous system (CNS) agents, including potential antidepressants, antipsychotics, and anxiolytics.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve lipophilicity and biological activity.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science: Employed in the synthesis of advanced polymers and liquid crystals where specific aromatic and amine functionalities are required.
• Chemical Biology Probe Synthesis: Useful for constructing molecular probes to study enzyme function and receptor interactions.

Basic Information

Product Name	2-(3-Trifluoromethyl-Phenyl)-Piperazine
CAS No.	74418-16-9
Molecular Formula	C11H13F3N2
Molecular Weight	230.23 g/mol
Synonyms	1-(3-(Trifluoromethyl)phenyl)piperazine; 3-Trifluoromethylphenylpiperazine; 1-(3-Trifluoromethylphenyl)piperazine; 3-(Trifluoromethyl)-1-piperazinobenzene; 3-(Piperazin-1-yl)benzotrifluoride; m-Trifluoromethylphenylpiperazine; TFMPP (context-specific); α-(3-Trifluoromethylphenyl)piperazine
EINECS	Contact for details

Quality Control

Every batch of 2-(3-Trifluoromethyl-Phenyl)-Piperazine is manufactured under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.