Description

5-Hydroxytryptophan Tetrakis(Trimethylsilyl) Deriv. is a key silylated derivative of the essential amino acid precursor 5-HTP, designed for advanced analytical and synthetic chemistry applications. This compound is critical for protecting sensitive functional groups, enabling precise analysis and facilitating complex multi-step organic syntheses. It is primarily utilized by research institutions, pharmaceutical development labs, and fine chemical manufacturers requiring high-purity, specialized intermediates for method development and process chemistry.

Application

• Gas Chromatography-Mass Spectrometry (GC-MS) Analysis: Serves as a volatile derivative for the accurate quantification and identification of 5-HTP and related tryptophan metabolites in complex biological matrices.
• Pharmaceutical Intermediate: Acts as a protected synthetic building block in the research and development of novel neuroactive compounds, antidepressants, and sleep aids.
• Metabolomics and Clinical Research: Used in the preparation of samples for profiling serotonin pathway metabolites in studies related to mood disorders, migraines, and neurological health.
• Reference Standard: Employed as a high-purity calibrant or internal standard in analytical method development and validation for regulatory compliance (e.g., FDA, ICH guidelines).
• Organic Synthesis Reagent: Facilitates reactions where the protection of hydroxyl and amine groups is necessary to achieve selective transformations in complex molecule construction.
• Nutritional Supplement Research: Supports analytical studies on the stability, bioavailability, and metabolism of 5-HTP in nutraceutical formulations.

Basic Information

Product Name	5-Hydroxytryptophan Tetrakis(Trimethylsilyl) Deriv.
CAS No.	74367-80-9
Molecular Formula	C26H55N2O3Si4
Molecular Weight	555.1 g/mol
Synonyms	5-HTP-TMS; 5-Hydroxytryptophan, tetrakis(trimethylsilyl) derivative; L-5-Hydroxytryptophan TMS derivative; N,O-Bis(trimethylsilyl)-5-(trimethylsilyloxy)tryptophan trimethylsilyl ester; Tryptophan, 5-hydroxy-, tetrakis(trimethylsilyl) deriv.; 5-HTP per-TMS; 5-Hydroxy-L-tryptophan tetrakis(trimethylsilyl) ether
EINECS	Contact for details

Quality Control

Our 5-Hydroxytryptophan Tetrakis(Trimethylsilyl) Deriv. is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and GC-MS for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic and volatile nature, the container should be allowed to reach ambient temperature before opening to minimize moisture ingress and product loss. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 95.0%
Purity (HPLC)	≥ 97.0%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.