Description

2-Oxoisovaleric Acid Trimethylsilyl Ester is a protected derivative of 2-oxoisovaleric acid, a key intermediate in organic synthesis. This compound is valued for its role as a versatile building block in the production of pharmaceuticals, agrochemicals, and advanced materials. It is primarily sought by R&D chemists and process development scientists in the fine chemical and pharmaceutical industries for applications requiring a stable, silylated precursor.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing modified amino acid or keto acid structures.
• Peptide & Amino Acid Chemistry: Used in the preparation of protected amino acid derivatives and in peptide synthesis strategies.
• Agrochemical Synthesis: Serves as a key intermediate in the development of herbicides, fungicides, and plant growth regulators.
• Organic Synthesis Reagent: Employed as a stable, volatile reagent for introducing the 2-oxoisovalerate moiety in complex molecular constructions.
• Material Science Research: Utilized in the development of novel polymers and specialty chemicals where specific branched-chain functionalities are required.
• Metabolic Pathway Studies: Acts as a precursor or standard in biochemical research related to branched-chain amino acid metabolism.

Basic Information

Product Name	2-Oxoisovaleric Acid Trimethylsilyl Ester
CAS No.	74367-70-7
Molecular Formula	C8H16O3Si
Molecular Weight	188.30 g/mol
Synonyms	2-Oxoisovaleric Acid TMS Ester; 2-Ketoisovaleric Acid Trimethylsilyl Ester; 3-Methyl-2-oxobutyric Acid Trimethylsilyl Ester; Trimethylsilyl 2-Oxoisovalerate; Trimethylsilyl 3-Methyl-2-oxobutyrate; 2-Oxoisovaleric Acid, Trimethylsilyl Ester; (Trimethylsilyl) 3-methyl-2-oxobutanoate; α-Ketoisovaleric Acid TMS Derivative
EINECS	Contact for details

Quality Control

Our 2-Oxoisovaleric Acid Trimethylsilyl Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee reliable performance in your sensitive synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.