Description

Indomethacin Sodium Salt Trihydrate is a water-soluble sodium salt derivative of the potent non-steroidal anti-inflammatory drug (NSAID) indomethacin. This form is critical for formulating stable, injectable pharmaceutical solutions and other dosage forms requiring enhanced solubility. It is primarily utilized by pharmaceutical manufacturers and research institutions in the development and production of anti-inflammatory and analgesic medications.

Application

• Pharmaceutical Active Ingredient (API): Core component in the manufacture of prescription anti-inflammatory and analgesic drugs.
• Injectable Formulations: Preferred for parenteral solutions due to its improved aqueous solubility compared to the free acid form.
• Research & Development: Used in preclinical and clinical studies investigating inflammation, pain mechanisms, and pharmacokinetics.
• Analytical Reference Standard: Serves as a high-purity standard for quality control (QC) and analytical method development in laboratories.
• Veterinary Pharmaceuticals: Applied in anti-inflammatory treatments for animal health.
• Topical Preparations: Incorporated into gels or creams where a soluble salt form is advantageous.

Basic Information

Product Name	Indomethacin Sodium Salt Trihydrate
CAS No.	74252-25-8
Molecular Formula	C19H15ClNNaO4 · 3H2O
Molecular Weight	433.78 g/mol (anhydrous basis)
Synonyms	Indomethacin Sodium Salt; Sodium Indomethacin Trihydrate; 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid sodium salt trihydrate; Indomethacin Na Salt; Indometacin Sodium Salt; MK-615 Sodium Salt; Indocid Sodium Salt; Indocin Sodium
EINECS	Contact for details

Quality Control

Our Indomethacin Sodium Salt Trihydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets stringent specifications suitable for pharmaceutical applications. Certificates of Analysis (COA) documenting compliance with relevant in-house or customer-specific standards are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC, anhydrous basis)	98.0% - 102.0%
Water Content (KF)	11.0% - 13.0% (Theoretical for Trihydrate: ~12.46%)
pH (1% Solution)	6.0 - 8.0
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.