Description

(3R,10Ar)-2,3,10,10A-Tetrahydro-6-Hydroxy-3-(Hydroxymethyl)-2-Methyl-3,10A-Bis(Methylthio)Pyrazino[1,2-A]Indole-1,4-Dione is a high-purity, complex heterocyclic compound with a defined stereochemistry, serving as a critical advanced intermediate in modern synthetic chemistry. Its unique pyrazinoindole-dione structure makes it a valuable building block for the development of novel pharmacologically active molecules. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of new chemical entities, particularly for exploring new therapeutic areas.

Application

• Pharmaceutical Intermediate: Key precursor in the research and development of new active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) or anti-infective drug candidates.
• Medicinal Chemistry Research: Used as a sophisticated scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Organic Synthesis Building Block: Employed in complex multi-step syntheses requiring a stereochemically defined, multifunctional intermediate.
• Biochemical Research: Potential use as a tool compound or probe in biochemical assays to study enzyme inhibition or receptor binding.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.
• Academic Research: Utilized in university laboratories for methodological development in synthetic organic chemistry and heterocyclic chemistry.

Basic Information

Product Name	(3R,10Ar)-2,3,10,10A-Tetrahydro-6-Hydroxy-3-(Hydroxymethyl)-2-Methyl-3,10A-Bis(Methylthio)Pyrazino[1,2-A]Indole-1,4-Dione
CAS No.	74149-39-6
Molecular Formula	C16H18N2O4S2
Molecular Weight	366.45 g/mol
Synonyms	Pyrazino[1,2-a]indole-1,4-dione, 2,3,10,10a-tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-3,10a-bis(methylthio)-, (3R,10aR)-; (3R,10aR)-3,10a-Bis(methylthio)-2-methyl-1,4-dioxo-1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indol-6-ol 3-methanol; 74149-39-6; Advanced Pyrazinoindole Intermediate; Stereospecific Heterocyclic Building Block
EINECS	Contact for details

Quality Control

Every batch of (3R,10Ar)-2,3,10,10A-Tetrahydro-6-Hydroxy-3-(Hydroxymethyl)-2-Methyl-3,10A-Bis(Methylthio)Pyrazino[1,2-A]Indole-1,4-Dione is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and strength, meeting the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) including chiral purity, assay, and impurity profile is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound may be light-sensitive and hygroscopic; therefore, containers should be kept sealed under an inert atmosphere when not in use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.