Description

Ketorolac Tromethamine is a non-steroidal anti-inflammatory drug (NSAID) salt form, specifically designed for enhanced solubility and stability in pharmaceutical formulations. This compound is critical for its potent analgesic and anti-inflammatory properties, offering a non-opioid option for managing moderate to severe pain. It is primarily required by pharmaceutical manufacturers and research institutions for the production of injectable and ophthalmic solutions, as well as in the development of novel analgesic drug delivery systems. Ketorolac Tromethamine CAS NO 74103-07-4 represents a high-value active pharmaceutical ingredient (API) for the global healthcare market.

Application

• Pharmaceutical API: Primary active ingredient in injectable formulations for postoperative and acute pain management.
• Ophthalmic Solutions: Used in eye drop formulations to treat ocular inflammation and pain following cataract surgery.
• Analgesic Research: Key reference standard and building block in preclinical and clinical research for new pain therapeutics.
• Generic Drug Manufacturing: Essential for the production of generic versions of branded ketorolac tromethamine medications.
• Hospital Formulary: Sourced by compounding pharmacies and hospital procurement for sterile preparation.
• Veterinary Medicine: Potential application in veterinary pharmaceuticals for pain relief in animals.

Basic Information

Product Name	Ketorolac Tromethamine
CAS No.	74103-07-4
Molecular Formula	C19H24N2O6 • C4H11NO3
Molecular Weight	376.41 (Ketorolac) + 121.14 (Tromethamine) = 497.55 g/mol (as salt)
Synonyms	(±)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1); Ketorolac Tromethamine Salt; Toradol® (Brand Name); Ketorolac Trometamol; (RS)-5-Benzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid trometamol salt; Ketorolac TRIS salt; Ketorolac Tromethamine USP
EINECS	Contact for details

Quality Control

Our Ketorolac Tromethamine is manufactured and tested to meet stringent pharmacopeial standards. Quality assurance protocols are designed to ensure identity, purity, strength, and composition. Our products undergo rigorous quality testing to ensure compliance with industry standards, including potential alignment with USP, EP, and ICH Q7 guidelines for active pharmaceutical ingredients. Certificates of Analysis (COA) detailing specific batch results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or controlled atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity: ≤ 0.5%; Total impurities: ≤ 2.0%
Specific Rotation	- Contact for details -
pH (1% Solution)	6.0 - 7.5

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.