Description

Ketorolac is a potent non-steroidal anti-inflammatory drug (NSAID) belonging to the pyrrolo-pyrrole group of carboxylic acids. Its primary value lies in its effective analgesic and anti-inflammatory properties, making it a critical active pharmaceutical ingredient (API) for managing moderate to severe pain. This compound is essential for pharmaceutical manufacturers developing injectable solutions, ophthalmic formulations, and oral tablets. Ketorolac CAS NO 74103-06-3 is supplied under stringent quality controls to meet the exacting standards of the global pharmaceutical industry.

Application

Ketorolac Tromethamine, the salt form of this API, is utilized in a variety of therapeutic formulations:

• Analgesic Injections: For the short-term management of moderately severe acute pain requiring analgesia at the opioid level, often in postoperative settings.
• Ophthalmic Solutions: Used to relieve ocular itching caused by seasonal allergic conjunctivitis and for the reduction of inflammation post-cataract surgery.
• Oral Tablet Formulations: Incorporated into solid dosage forms for continued pain management following initial parenteral therapy.
• Pharmaceutical Intermediates: Serves as a key starting material or intermediate in the synthesis of more complex drug molecules or derivative forms.
• Research & Development: Used in preclinical and clinical studies focusing on pain mechanisms, inflammation pathways, and new drug delivery systems.
• Generic Drug Manufacturing: A vital component for companies producing bioequivalent generic versions of branded ketorolac medications.

Basic Information

Product Name	Ketorolac
CAS No.	74103-06-3
Molecular Formula	C15H13NO3
Molecular Weight	255.27 g/mol
Synonyms	(±)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid; Ketorolac Free Acid; RS-37619; Toradol (brand name, typically refers to the tromethamine salt); Torolac; Acular (ophthalmic brand); Ketanov; Droal; Tarasyn; Ketorol
EINECS	Contact for details

Quality Control

Our Ketorolac is manufactured and tested to meet high-purity standards suitable for pharmaceutical applications. Quality assurance protocols are designed to ensure batch-to-batch consistency, identity, purity, and strength. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and other critical parameters. We adhere to cGMP (current Good Manufacturing Practice) guidelines, and our quality system supports compliance with major pharmacopoeial standards such as USP and EP upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. The original container should be kept tightly sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	NMT 1.0%
Related Substances (HPLC)	Total impurities: NMT 1.0% Any individual impurity: NMT 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	NMT 20 ppm
Sulfated Ash	NMT 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.