Description

trans-Doxercalciferol is a synthetic analog of vitamin D2, specifically engineered for enhanced biological activity and stability. This compound is critical for applications requiring precise control over calcium and phosphorus metabolism. It is primarily utilized by the pharmaceutical industry for the development of treatments targeting conditions such as secondary hyperparathyroidism associated with chronic kidney disease.

Application

• Active Pharmaceutical Ingredient (API) in medications for renal osteodystrophy and secondary hyperparathyroidism.
• Research and Development of novel vitamin D receptor (VDR) agonists for metabolic bone disorders.
• Biochemical Research as a reference standard in analytical method development and validation.
• Preclinical Studies investigating the role of vitamin D analogs in immune modulation and cell differentiation.
• Formulation Development for injectable and oral dosage forms requiring high-purity vitamin D analogs.

Basic Information

Product Name	trans-Doxercalciferol
CAS No.	74007-20-8
Molecular Formula	C₂₈H₄₄O₂
Molecular Weight	412.65 g/mol
Synonyms	1α-Hydroxyergocalciferol; 1α-OH-D2; 1α-Hydroxyvitamin D2; Hectorol (brand name); 1α-Hydroxy-5,6-trans-vitamin D2; (5E,7E,22E)-1α-Hydroxyergocalcifera-5,7,10(19),22-tetraen-3-ol; 1α-Hydroxy-5,6-trans-ergocalciferol
EINECS	Contact for details

Quality Control

Our trans-Doxercalciferol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets stringent pharmaceutical-grade specifications. Certificates of Analysis (COA) detailing all test results are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F). The container should be kept in a dry, well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.