Description

1-(3,4,5-Trimethoxyphenyl)-1,2,3,4-Tetrahydropyrrolo[1,2-A]Pyrazine is a high-purity, complex heterocyclic compound that serves as a critical advanced intermediate in modern organic synthesis. Its unique fused pyrrolopyrazine core functionalized with a trimethoxyphenyl group makes it a valuable scaffold for pharmaceutical research and development. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates targeting central nervous system (CNS) disorders, oncology, and other therapeutic areas.
• Chemical Biology Probe: Used in research to study enzyme inhibition, receptor binding, and other biological mechanisms due to its privileged structure.
• Agrochemical Research: Serves as a precursor in the development of new herbicides, fungicides, or insecticides with novel modes of action.
• Material Science Precursor: Potential starting material for creating organic semiconductors, ligands for catalysts, or specialty polymers.
• Academic & Contract Research: Essential for methodological studies in organic chemistry, including novel cyclization and functionalization reactions.
• Custom Synthesis & Scale-Up: Supplied for process optimization and pilot-scale production under cGMP or ISO quality frameworks for clinical trial material.

Basic Information

Product Name	1-(3,4,5-Trimethoxyphenyl)-1,2,3,4-Tetrahydropyrrolo[1,2-A]Pyrazine
CAS No.	73627-27-7
Molecular Formula	C₁₇H₂₀N₂O₃
Molecular Weight	300.36 g/mol
Synonyms	1-(3,4,5-Trimethoxyphenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine; Pyrrolo[1,2-a]pyrazine, 1-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydro-; 1,2,3,4-Tetrahydropyrrolo[1,2-a]pyrazine, 1-(3,4,5-trimethoxyphenyl)-; 73627-27-7; 1-(3,4,5-Trimethoxyphenyl)-1,2,3,4-tetrahydropyrazino[1,2-a]indole (obsolete); TMP-THP; 3,4,5-Trimethoxyphenyl pyrrolopyrazine derivative
EINECS	Contact for details

Quality Control

Every batch of 1-(3,4,5-Trimethoxyphenyl)-1,2,3,4-Tetrahydropyrrolo[1,2-A]Pyrazine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency, supporting regulatory filings and process validation. A detailed Certificate of Analysis (COA) including HPLC purity, NMR, and MS data is supplied with each shipment. Our quality standards align with ICH guidelines and we can support production under cGMP conditions for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be light-sensitive and should be handled under an inert atmosphere for long-term storage to prevent potential oxidation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure (¹H & ¹³C)
Purity (HPLC)	≥ 97.0% (Area %)
Related Substances (HPLC)	Total impurities ≤ 3.0%
Single Maximum Impurity	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5% w/w
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.