Description

11-Hydroxy-5,8,12,14-Eicosatetraenoic Acid is a specialized hydroxy fatty acid derivative of arachidonic acid, serving as a key intermediate in the study of eicosanoid biosynthesis and lipid signaling pathways. Its value lies in its role as a biochemical tool for researching inflammation, immune response, and cellular regulation mechanisms. This compound is essential for pharmaceutical R&D laboratories, academic institutions, and biotechnology companies focused on developing novel therapeutics or advancing fundamental lipidomics research.

Application

• Biochemical Research Standard: Used as a high-purity reference standard in analytical laboratories for the quantification and identification of related eicosanoids via LC-MS, HPLC, or GC-MS.
• Enzymatic Pathway Studies: Serves as a substrate or intermediate in in vitro studies to investigate the activity of lipoxygenase (LOX) and cytochrome P450 enzymes involved in arachidonic acid metabolism.
• Inflammation & Immunology Research: Employed in cell-based assays and animal models to probe the biological effects and signaling roles of specific hydroxyeicosatetraenoic acids (HETEs) in inflammatory processes.
• Pharmaceutical Development: Acts as a critical building block or a pharmacological probe in the discovery and development of new anti-inflammatory or immunomodulatory drug candidates.
• Metabolomics & Lipidomics: An important analyte for profiling oxylipins in biological samples, aiding in the understanding of disease biomarkers and metabolic states.

Basic Information

Product Name	11-Hydroxy-5,8,12,14-Eicosatetraenoic Acid
CAS No.	73151-66-3
Molecular Formula	C₂₀H₃₂O₃
Molecular Weight	320.47 g/mol
Synonyms	11-HETE; 11-Hydroxyeicosatetraenoic Acid; 11(S)-HETE; (11S)-11-Hydroxyicosa-5Z,8Z,12E,14Z-tetraenoic Acid; 11-Hydroxy-5Z,8Z,12E,14Z-eicosatetraenoic Acid; 11(S)-Hydroxy-5,8,12,14-eicosatetraenoic Acid; 11-Hydroxyarachidonic Acid
EINECS	Contact for details

Quality Control

Every batch of 11-Hydroxy-5,8,12,14-Eicosatetraenoic Acid is produced and analyzed under strict quality management protocols. We ensure high purity and batch-to-batch consistency through advanced analytical techniques. A comprehensive Certificate of Analysis (COA), detailing purity, identity, and impurity profiles as determined by HPLC, NMR, and MS, is provided with each shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. Keep the container in a dry, well-ventilated area designated for laboratory chemicals.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Assay	≥ 90% (by weight)
Isomeric Purity	≥ 98% (11(S)-isomer)
Solubility	Soluble in ethanol, DMSO; slightly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.