Description

1-S-Phosphocholine-2-o-Hexadecanoyl-1-Mercapto-2-Ethanol is a specialized synthetic phospholipid derivative, a key intermediate in advanced lipid research and pharmaceutical development. This compound is crucial for its role in the synthesis of novel liposomal drug delivery systems and as a building block for creating functionalized membrane components. It is primarily utilized by research institutions and pharmaceutical companies focused on targeted therapeutics, vaccine adjuvants, and advanced biomaterial science.

Application

• Lipid Nanoparticle (LNP) Formulation: A critical component in the development of mRNA and siRNA delivery vehicles for gene therapy and vaccine platforms.
• Liposome Engineering: Used to synthesize functionalized phospholipids for creating stealth or targeted liposomes with enhanced stability and specific cell-targeting capabilities.
• Biomembrane Research: Serves as a model compound for studying membrane fluidity, permeability, and the incorporation of thiol-reactive groups into lipid bilayers.
• Pharmaceutical Intermediates: Acts as a key synthetic precursor for novel phospholipid-based prodrugs and active pharmaceutical ingredients (APIs).
• Diagnostic Agent Development: Utilized in the creation of contrast agents or probes for medical imaging techniques that require specific lipid conjugation.

Basic Information

Product Name	1-S-Phosphocholine-2-o-Hexadecanoyl-1-Mercapto-2-Ethanol
CAS No.	73130-93-5
Molecular Formula	C23H48NO6PS
Molecular Weight	497.66 g/mol
Synonyms	1-S-Phosphocholine-2-o-Hexadecanoyl-1-Mercapto-2-Ethanol; 1-Palmitoyl-2-mercapto-sn-glycero-3-phosphocholine; 1-Hexadecanoyl-2-mercapto-sn-glycero-3-phosphocholine; 2-Mercapto-1-palmitoyl-sn-glycero-3-phosphocholine; Thiolated Phosphatidylcholine Derivative; PC(SH); Functionalized Phospholipid; Mercapto Phospholipid
EINECS	Contact for details

Quality Control

Our 1-S-Phosphocholine-2-o-Hexadecanoyl-1-Mercapto-2-Ethanol is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the stringent requirements for research and pharmaceutical development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical parameters such as assay, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and hydrolysis. The material is hygroscopic and should be handled in a dry environment. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 2.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.