Description

Atractylenolide-1 is a bioactive sesquiterpene lactone, a key marker compound for the quality and standardization of medicinal herbs like Atractylodes macrocephala. This high-purity reference standard is essential for ensuring product consistency, efficacy, and safety in research and manufacturing. It is primarily sought by analytical laboratories, pharmaceutical R&D teams, and nutraceutical producers engaged in quality control, phytochemical analysis, and the development of standardized botanical extracts.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification and quantification of Atractylenolide-1 in raw materials and finished herbal products.
• Analytical Research & Method Development: Serves as a critical standard for HPLC, UPLC, and LC-MS analysis in pharmacokinetic, metabolic, and stability studies.
• Bioactivity & Pharmacological Research: Investigated for its potential anti-inflammatory, anti-cancer, and gastrointestinal regulatory properties in preclinical studies.
• Quality Control for TCM & Herbal Extracts: Essential for standardizing extracts of Atractylodes macrocephala (Bai Zhu) to ensure batch-to-batch consistency and meet pharmacopoeial specifications.
• Nutraceutical Standardization: Employed to assay and guarantee the potency of dietary supplements containing Atractylodes macrocephala.
• Academic & Institutional Research: Used in universities and research institutes for phytochemical isolation, structural elucidation, and biological screening projects.

Basic Information

Item	Details
Product Name	Atractylenolide-1
CAS No.	73069-13-3
Molecular Formula	C15H18O2
Molecular Weight	230.30 g/mol
Synonyms	(3aS,6aR,9aS,9bR)-3a,4,5,8,9,9a-Hexahydro-3,6,9-trimethylen-azuleno[4,5-b]furan-2(3H)-one; Atractylenolide I; Atractylenolide I; Atractylolide I; [4,5-b]Furan-2(3H)-one, 3a,4,5,8,9,9a-hexahydro-3,6,9-trimethylenazuleno-; Atractylenolide
EINECS	Contact for details

Quality Control

Our Atractylenolide-1 is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and spectroscopic methods (NMR, MS) for structural confirmation, to ensure it meets the stringent requirements for use as a reference standard. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact purity and full analytical results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤10 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.