Description

1-Deoxyforskolin is a key forskolin derivative, a diterpenoid compound of significant interest in biochemical research and development. Its primary value lies in its role as a structural analog for studying adenylate cyclase activity and cellular signaling pathways without the potent stimulatory effects of forskolin. This makes it an essential research chemical for pharmaceutical discovery, particularly in metabolic and cardiovascular research. Industrial buyers in the life sciences sector rely on this high-purity compound for consistent, reliable performance in critical applications.

Application

• Biochemical Research: Used as a critical reference standard and negative control in studies of adenylate cyclase activation and cAMP pathway modulation.
• Pharmaceutical R&D: Serves as a lead compound or intermediate for the synthesis and development of novel therapeutic agents targeting metabolic disorders.
• Cell Signaling Studies: Employed in vitro to investigate G-protein-coupled receptor (GPCR) function and intracellular secondary messenger systems.
• Enzyme Inhibition Assays: Utilized to study the specificity and mechanism of diterpene interactions with enzymatic targets.
• Natural Product Chemistry: Acts as a standard for the analysis, purification, and quality control of forskolin and related Coleus forskohlii extracts.
• Academic Research: Fundamental tool in university and institutional labs for teaching and exploring diterpenoid biochemistry and pharmacology.

Basic Information

Product Name	1-Deoxyforskolin
CAS No.	72963-77-0
Molecular Formula	C22H32O6
Molecular Weight	392.49 g/mol
Synonyms	1-Deoxyforskolin; 7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one; (1R,4aS,5S,6S,7R,7aS,10aS,10bS)-7-(Acetyloxy)-1,5,6,7a-tetrahydroxy-1,4a,7,10a-tetramethyl-3-oxo-1,4a,5,6,7,7a,8,9,10,10a,10b,11-dodecahydro-2H-5,8a-methanocyclohepta[a]naphthalen-6-yl acetate; Forskolin derivative; Deoxyforskolin
EINECS	Contact for details

Quality Control

Our 1-Deoxyforskolin is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and spectroscopic methods for structural confirmation. A Certificate of Analysis (COA) detailing identity, purity, and related substances is provided with every shipment. We adhere to relevant industry guidelines to support our customers' quality and compliance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.