Description

2,5-Piperazinedione,3,6-Diethyl-,trans-(9Ci) CAS NO 72882-82-7 is a specialized heterocyclic organic compound belonging to the piperazinedione (diketopiperazine) class. This compound serves as a valuable chiral building block and synthetic intermediate in advanced organic synthesis, particularly for the development of complex molecules. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of peptides, bioactive compounds, and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for peptide-mimetics and constrained scaffolds.
• Peptidomimetic Chemistry: Used to construct diketopiperazine (DKP) cores, which are privileged structures in medicinal chemistry for modulating biological activity and improving metabolic stability.
• Asymmetric Synthesis: Employed as a starting material or intermediate in stereoselective synthesis due to its defined trans-configuration and ethyl substituents.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in enantioselective transformations.
• Academic and Industrial Research: A valuable compound for chemical libraries and exploratory research in organic chemistry and drug discovery programs.
• Fine Chemical Production: Used in the multi-step synthesis of specialty chemicals, agrochemicals, and other high-value, complex organic molecules.

Basic Information

Product Name	2,5-Piperazinedione,3,6-Diethyl-,trans-(9Ci)
CAS No.	72882-82-7
Molecular Formula	C8H14N2O2
Molecular Weight	170.21 g/mol
Synonyms	trans-3,6-Diethyl-2,5-piperazinedione; trans-3,6-Diethylpiperazine-2,5-dione; 3,6-Diethyl-2,5-diketopiperazine (trans); (3R,6R)-3,6-Diethylpiperazine-2,5-dione; (3S,6S)-3,6-Diethylpiperazine-2,5-dione; Diketopiperazine, 3,6-diethyl-, trans-; 2,5-Diketopiperazine, 3,6-diethyl-, trans-
EINECS	Contact for details

Quality Control

Our 2,5-Piperazinedione,3,6-Diethyl-,trans-(9Ci) is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity verification, to ensure it meets the stringent requirements for research and synthesis. Certificates of Analysis (COA) detailing identity, purity, and specific test results are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de (trans-isomer)
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.