Description

Br-Peg6-Bromide is a bifunctional polyethylene glycol (PEG) derivative featuring a bromine atom at each terminus, serving as a versatile heterobifunctional linker. This compound is crucial for introducing PEG spacers into molecules, enhancing solubility, reducing immunogenicity, and improving pharmacokinetic properties. It is primarily utilized by researchers and manufacturers in the pharmaceutical, bioconjugation, and materials science sectors for drug delivery system development, surface functionalization, and the synthesis of complex polymer architectures.

Application

• Pharmaceutical Linker: A key building block for creating antibody-drug conjugates (ADCs) and PEGylated therapeutics to improve drug stability and targeting.
• Polymer Chemistry: Serves as an initiator or chain extender in the synthesis of functionalized polymers and block copolymers.
• Surface Modification: Used to PEGylate nanoparticles, quantum dots, and other surfaces to impart stealth properties and prevent non-specific binding.
• Bioconjugation: Facilitates the covalent attachment of proteins, peptides, or other biomolecules to drugs, dyes, or solid supports via the reactive bromine ends.
• Cross-linking Agent: Employed in the preparation of hydrogels and polymer networks for controlled release applications.
• Intermediate for Further Functionalization: The bromide groups can be readily substituted to introduce other functional groups like amines, azides, or alkynes for click chemistry.

Basic Information

Product Name	Br-Peg6-Bromide
CAS No.	72713-23-6
Molecular Formula	C14H28Br2O5
Molecular Weight	436.18 g/mol
Synonyms	1,11-Dibromo-3,6,9-trioxaundecane; α,ω-Dibromo-hexaethylene glycol; Hexaethylene glycol dibromide; Bis(2-bromoethyl) ether of tetraethylene glycol; 2,2'-(Ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl) bis(2-bromoacetate) (IUPAC-like); PEG-6 dibromide; Dibromo-PEG6; Br-(CH2CH2O)6-CH2CH2-Br
EINECS	Contact for details

Quality Control

Our Br-Peg6-Bromide is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and production. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.