Description

12(S)-Hetre is a high-purity, chiral hydroxy fatty acid derivative of significant interest in advanced biochemical research and synthesis. This compound serves as a critical building block and reference standard for the development of bioactive lipid mediators and specialized pharmaceutical intermediates. It is essential for researchers and manufacturers in the pharmaceutical, cosmeceutical, and life science sectors requiring precise stereochemical control.

Application

• Pharmaceutical Intermediate: Key chiral precursor for the synthesis of specialized pro-resolving lipid mediators (SPMs) and other bioactive eicosanoids.
• Biochemical Research: Used as a high-purity reference standard in lipidomics, inflammation studies, and metabolic pathway analysis.
• Cosmeceutical Actives: Incorporated into advanced skincare formulations targeting anti-inflammatory and skin barrier repair functions.
• Academic & Industrial R&D: Serves as a critical reagent for studying lipoxygenase pathways and developing novel therapeutic agents.
• Diagnostic Development: Utilized in the production of calibration standards and assay kits for clinical lipid analysis.

Basic Information

Product Name	12(S)-Hetre
CAS No.	72710-10-2
Molecular Formula	C20H32O4
Molecular Weight	336.47 g/mol
Synonyms	12(S)-HETRE; 12(S)-HETE; 12S-Hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid; 12(S)-HETE; 12(S)-Hydroxyeicosatetraenoic Acid; 12S-HETE; (12S)-Hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid; 12-HETE, (S)-Isomer
EINECS	Contact for details

Quality Control

Our 12(S)-Hetre is manufactured under strict quality systems to ensure batch-to-batch consistency and high stereochemical purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), and impurity profiles. We adhere to cGMP principles for pharmaceutical-grade materials, and specifications can be aligned with relevant pharmacopeial standards upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% (12S isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.