Description

2,4-Bis(o-Methoxypolyethylene Glycol)-6-Chloro-S-Triazine is a specialized, reactive PEGylated derivative of cyanuric chloride, designed for the covalent modification of biomolecules and surfaces. This compound matters for its ability to introduce biocompatible, hydrophilic polyethylene glycol (PEG) chains, which is a critical strategy for reducing immunogenicity, improving solubility, and enhancing the circulation time of therapeutic agents. It is primarily needed by researchers and manufacturers in the bioconjugation, pharmaceutical development, and advanced materials sectors for creating PEGylated drugs, diagnostic reagents, and functionalized polymers.

Application

• Bioconjugation and PEGylation: A key reagent for the site-specific attachment of polyethylene glycol (PEG) chains to proteins, peptides, antibodies, and oligonucleotides to improve their pharmacokinetic properties.
• Pharmaceutical Development: Used in the research and production of long-acting injectable therapeutics, where PEGylation enhances stability and reduces dosing frequency.
• Diagnostic Reagents: Employed to modify surfaces of nanoparticles, microspheres, or biosensors with PEG linkers to minimize non-specific binding and improve assay performance.
• Polymer Functionalization: Serves as a heterobifunctional crosslinker or modifier to introduce reactive chloro-s-triazine groups and hydrophilic PEG spacers into polymer backbones or hydrogels.
• Surface Engineering: Applied to create non-fouling, biocompatible coatings on medical devices, implants, and chromatographic media by grafting PEG layers.
• Drug Delivery Systems: Facilitates the development of targeted drug delivery platforms by providing a reactive handle (chloro group) for subsequent coupling with targeting ligands.

Basic Information

Product Name	2,4-Bis(o-Methoxypolyethylene Glycol)-6-Chloro-S-Triazine
CAS No.	72708-10-2
Molecular Formula	CnH2n+1OnClN3 (Variable, PEG chain length dependent)
Molecular Weight	Variable (Depends on PEG chain length 'n')
Synonyms	2,4-Bis(mPEG)-6-chloro-1,3,5-triazine; PEGylated cyanuric chloride; mPEG2-chlorotriazine; 6-Chloro-2,4-bis(methoxypolyethylene glycol)-1,3,5-triazine; Bifunctional PEG-chlorotriazine; Chloro-s-triazine PEG derivative; Reactive PEG crosslinker; 2,4-Di(mPEG-yl)-6-chloro-s-triazine
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure batch-to-batch consistency and compliance with research-grade standards. Each lot is characterized for critical parameters including PEG chain length distribution (by GPC/SEC), degree of functionalization, and reactive chlorine content. Certificates of Analysis (COA) detailing purity, assay, and identification are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to prevent condensation. For long-term storage under inert atmosphere, please contact us.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or waxy solid
Identification (IR)	Conforms to structure
PEG Average Molecular Weight (Mn)	As per order (e.g., 550, 750, 2000, 5000 Da)
Assay (Active Chlorine Content)	≥ 95% (Theoretical)
Purity (HPLC)	≥ 90% (by area)
Water Content (KF)	≤ 1.0 %
Solubility	Soluble in water, DMSO, DMF, chloroform

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.