Description

24,24-Difluoro-1,25-Dihydroxyvitamin D3 is a fluorinated analog of the active form of Vitamin D, Calcitriol, designed for enhanced metabolic stability and targeted biological activity. This compound is critical for researchers and developers in the pharmaceutical and life sciences sectors seeking to modulate Vitamin D receptor (VDR) pathways with greater precision. It is primarily utilized in advanced research applications, including the development of novel therapeutics for conditions related to calcium homeostasis, cell differentiation, and immune modulation.

Application

• Pharmaceutical Reference Standard: Serves as a high-purity certified standard for analytical method development and quality control in drug manufacturing.
• Biochemical Research: Used as a key tool compound to study the structure-activity relationship (SAR) of Vitamin D analogs and VDR signaling mechanisms.
• Drug Discovery & Development: Acts as a crucial intermediate or active pharmaceutical ingredient (API) in the R&D pipeline for new treatments targeting osteoporosis, psoriasis, and certain cancers.
• Metabolic Studies: Employed in preclinical research to investigate the impact of fluorination on the metabolic profile and biological half-life of Vitamin D analogs.

Basic Information

Product Name	24,24-Difluoro-1,25-Dihydroxyvitamin D3
CAS No.	72696-49-2
Molecular Formula	C₂₇H₄₂F₂O₃
Molecular Weight	452.62 g/mol
Synonyms	1,25-Dihydroxy-24,24-difluorovitamin D3; 24,24-Difluoro-1α,25-dihydroxycholecalciferol; 24,24-Difluorocalcitriol; Falecalcitriol Impurity; (5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1α,3β,25-triol, 24,24-difluoro-; Vitamin D3 analog, 24,24-difluoro-1,25-dihydroxy-
EINECS	Contact for details

Quality Control

Our 24,24-Difluoro-1,25-Dihydroxyvitamin D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for research and development use. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. This product is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere or in a controlled, dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.