Description

1,2-Di-0-Dodecyl-Sn-Glycero-3-Phosphocholine is a synthetic, saturated phospholipid belonging to the phosphatidylcholine class, widely recognized for its role in forming stable, well-defined lipid bilayers. Its primary value lies in its ability to serve as a critical component in the fabrication of model membranes, liposomes, and other lipid-based delivery systems. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors, particularly for applications in drug delivery, membrane biophysics studies, and the development of diagnostic assays.

Application

• Liposome and Nanoparticle Formulation: A key structural lipid for creating unilamellar vesicles (LUVs, SUVs) and solid lipid nanoparticles (SLNs) for drug encapsulation and targeted delivery.
• Model Membrane Systems: Used to construct supported lipid bilayers (SLBs) and giant unilamellar vesicles (GUVs) for fundamental biophysical research on membrane protein interactions, permeability, and fusion.
• Biomimetic Coatings: Employed in surface modification to create non-fouling, cell-membrane-mimicking interfaces for biosensors, implants, and diagnostic devices.
• Cell Culture & Transfection Reagents: A component in specialized cell culture media supplements and as a helper lipid in non-viral transfection reagent formulations.
• Analytical Standards: Serves as a high-purity reference standard in lipidomics, mass spectrometry, and chromatography for qualitative and quantitative analysis.
• Cosmetic & Dermal Formulations: Used in advanced cosmetic products as a skin-identical lipid to enhance skin barrier function and delivery of active ingredients.

Basic Information

Product Name	1,2-Di-0-Dodecyl-Sn-Glycero-3-Phosphocholine
CAS No.	72593-72-7
Molecular Formula	C38H78NO8P
Molecular Weight	732.00 g/mol
Synonyms	1,2-Di-O-dodecyl-sn-glycero-3-phosphocholine; Dilauroylphosphatidylcholine, ether-linked; DLPCE; 1,2-Di-O-dodecyl-rac-glycero-3-phosphocholine; Ether PC(24:0); 1,2-Dilauroyl-sn-glycero-3-phosphocholine (ether analog); DDPC; 3-sn-Phosphatidylcholine, 1,2-di-O-dodecyl-
EINECS	Contact for details

Quality Control

Our 1,2-Di-0-Dodecyl-Sn-Glycero-3-Phosphocholine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the stringent requirements for research and formulation. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment. We can support compliance needs for cGMP, ISO, and other relevant regulatory frameworks upon request.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic and easily oxidized nature, store under an inert atmosphere (argon or nitrogen) at -20°C or below for long-term stability. For short-term use, store desiccated at 2-8°C. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.